Folding and association of a homotetrameric protein complex in an all-atom Go model

被引：6

作者：

Berhanu, W. M. ^{[1
]}

Jiang, P. ^{[1
]}

Hansmann, U. H. E. ^{[1
]}

机构：

[1] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA

来源：

PHYSICAL REVIEW E | 2013年 / 87卷 / 01期

基金：

美国国家卫生研究院;

关键词：

NONNATIVE INTERACTIONS; MOLECULAR-DYNAMICS; NATIVE TOPOLOGY; SIMULATIONS; MINIPROTEIN; STABILITY; MECHANISM; PATHWAYS; KINETICS; RESIDUE;

D O I：

10.1103/PhysRevE.87.014701

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

The 84-residue homotetrameric BBAT1 is one of the smallest stable protein complexes and therefore is a good test system to study the self-assembly of multimeric proteins. We have researched for this protein the interplay between the folding of monomers and their assembly into tetramers. Replica exchange molecular dynamics simulations relying on a Go model are compared with earlier simulations that use the physics-based coarse-grained UNRES model. DOI: 10.1103/PhysRevE.87.014701

引用

页数：5

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