Combinatorial RNAi:: a method for evaluating the functions of gene families in Drosophila

被引：42

作者：

Schmid, A ^{[1
]}

Schindelholz, B ^{[1
]}

Zinn, K ^{[1
]}

机构：

[1] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

TRENDS IN NEUROSCIENCES | 2002年 / 25卷 / 02期

关键词：

D O I：

10.1016/S0166-2236(02)02034-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Individual members of gene families often have partially redundant functions during nervous system development, making conventional genetic analysis problematic. Here we review experiments showing that several genes can be silenced together by injection of double-stranded RNAs into wild-type Drosophila embryos. By dye-labeling single neuroblasts in injected embryos, the effects of multigene silencing on individual CNS axon pathways can now be examined.

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页码：71 / 74

页数：4

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