In Vitro Activity of Tedizolid Against Gram-Positive Bacteria in Patients With Skin and Skin Structure Infections and Hospital-Acquired Pneumonia: A Korean Multicenter Study

被引：21

作者：

Lee, Yangsoon ^{[1
]}

Hong, Sung Kuk ^{[2
]}

Choi, SungHak ^{[3
]}

Weonbinlm ^{[3
]}

Yong, Dongeun ^{[2
]}

Lee, Kyungwon ^{[2
]}

机构：

[1] Hanyang Univ Coll Med, Dept Lab Med, Seoul, South Korea

[2] Yonsei Univ Coll Med, Res Inst Bacterial Resistance, Dept Lab Med, Seoul 120752, South Korea

[3] Dong A ST Res Inst, Yongin, South Korea

来源：

ANNALS OF LABORATORY MEDICINE | 2015年 / 35卷 / 05期

关键词：

Tedizolid; Skin; Soft tissue; Infection; Pneumonia; Gram-positive bacteria; RESISTANT STAPHYLOCOCCUS-AUREUS; ANAEROBIC-BACTERIA; STRAINS; TR-700; SUSCEPTIBILITY; SPECTRUM;

D O I：

10.3343/alm.2015.35.5.523

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

We compared the activities of tedizolid to those of linezolid and other commonly used antimicrobial agents against gram-positive cocci recovered from patients with skin and skin structure infections (SSSIs) and hospital-acquired pneumonia (HAP) in Korean hospitals. Gram-positive isolates were collected from 356 patients with SSSIs and 144 patients with HAP at eight hospitals in Korea from 2011 to 2014. SSSIs included impetigo, cellulitis, erysipelas, furuncles, abscesses, and infected burns. Antimicrobial susceptibility was tested by using the CLSI agar dilution method. All of the gram-positive isolates were inhibited by <= 1 mu g/mL tedizolid. The minimum inhibitory concentration [MIC](90) of tedizolid was 0.5 mu g/mL for methicillin-resistant Staphylococcus aureus, which was 4-fold lower than that of linezolid. Tedizolid may become a useful option for the treatment of SSSIs and HAP caused by gram-positive bacteria.

引用

页码：523 / 530

页数：8

共 15 条

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