The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation

被引：26
作者：
Holland, Andrew J.
Cleveland, Don W.
机构：
[1] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2012年 / 122卷 / 12期
关键词：
SPINDLE-ASSEMBLY CHECKPOINT; MAMMALIAN-CELLS; ANEUPLOIDY; INSTABILITY; CANCER; SEGREGATION; ANAPHASE;
D O I：
10.1172/JCI66420
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.
引用
收藏
页码：4325 / 4328
页数：4
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