The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation

被引：26
作者：
Holland, Andrew J.
Cleveland, Don W.
机构：
[1] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2012年 / 122卷 / 12期
关键词：
SPINDLE-ASSEMBLY CHECKPOINT; MAMMALIAN-CELLS; ANEUPLOIDY; INSTABILITY; CANCER; SEGREGATION; ANAPHASE;
D O I：
10.1172/JCI66420
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors through a function independent of its previously identified role in the mitotic checkpoint. Usp44-null animals develop aneuploidy and experience increased rates of tumorigenesis, implicating USP44 as novel tumor suppressor.
引用
收藏
页码：4325 / 4328
页数：4
相关论文
共 19 条
  • [1] Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair
    Araki, M
    Masutani, C
    Takemura, M
    Uchida, A
    Sugasawa, K
    Kondoh, J
    Ohkuma, Y
    Hanaoka, F
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (22) : 18665 - 18672
  • [2] Merotelic kinetochore orientation, aneuploidy, and cancer
    Cimini, Daniela
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2008, 1786 (01): : 32 - 40
  • [3] RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation
    Fuchs, Gilad
    Shema, Efrat
    Vesterman, Rita
    Kotler, Eran
    Wolchinsky, Zohar
    Wilder, Sylvia
    Golomb, Lior
    Pribluda, Ariel
    Zhang, Feng
    Haj-Yahya, Mahmood
    Feldmesser, Ester
    Brik, Ashraf
    Yu, Xiaochun
    Hanna, Jacob
    Aberdam, Daniel
    Domany, Eytan
    Oren, Moshe
    [J]. MOLECULAR CELL, 2012, 46 (05) : 662 - 673
  • [4] A mechanism linking extra centrosomes to chromosomal instability
    Ganem, Neil J.
    Godinho, Susana A.
    Pellman, David
    [J]. NATURE, 2009, 460 (7252) : 278 - U146
  • [5] Holland AJ, 2012, EMBO REP, V13, P501, DOI 10.1038/embor.2012.55
  • [6] Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
    Holland, Andrew J.
    Cleveland, Don W.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (07) : 478 - 487
  • [7] Breaking the chains: structure and function of the deubiquitinases
    Komander, David
    Clague, Michael J.
    Urbe, Sylvie
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (08) : 550 - 563
  • [8] Genetic instability in colorectal cancers
    Lengauer, C
    Kinzler, KW
    Vogelstein, B
    [J]. NATURE, 1997, 386 (6625) : 623 - 627
  • [9] MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells
    Michel, LS
    Liberal, V
    Chatterjee, A
    Kirchwegger, R
    Pasche, B
    Gerald, W
    Dobles, M
    Sorger, PK
    Murty, VVVS
    Benezra, R
    [J]. NATURE, 2001, 409 (6818) : 355 - 359
  • [10] The spindle-assembly checkpoint in space and time
    Musacchio, Andrea
    Salmon, Edward D.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (05) : 379 - 393
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