Mechanisms for Sweetness

被引：79
作者：
Fernstrom, John D. [1 ]
Munger, Steven D. [2 ]
Sclafani, Anthony [3 ]
de Araujo, Ivan E. [4 ,5 ]
Roberts, Ashley [6 ]
Molinary, Samuel [7 ]
机构：
[1] Univ Pittsburgh, Sch Med, Pittsburgh, PA 15260 USA
[2] Univ Maryland, Sch Med, Baltimore, MA USA
[3] CUNY, Brooklyn Coll, Brooklyn, NY 11210 USA
[4] John B Pierce Fdn Lab, New Haven, CT 06519 USA
[5] Yale Univ, Sch Med, New Haven, CT USA
[6] CANTOX, Mississauga, ON, Canada
[7] Tate & Lyle, Beaufort, SC USA
来源：
JOURNAL OF NUTRITION | 2012年 / 142卷 / 06期
关键词：
GLUCAGON-LIKE PEPTIDE-1; CONDITIONED FLAVOR PREFERENCES; MAMMALIAN TASTE RECEPTORS; TYPE-2; DIABETES-MELLITUS; ARTIFICIAL SWEETENER; REBAUDIOSIDE-A; FOOD REWARD; ALPHA-GUSTDUCIN; BITTER TASTE; GLUCOSE-ABSORPTION;
D O I：
10.3945/jn.111.149567
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
A remarkable amount of information has emerged in the past decade regarding sweet taste physiology. This article reviews these data, with a particular focus on the elucidation of the sweet taste receptor, its location and actions in taste transduction in the mouth, its nontaste functions in the gastrointestinal tract (e.g., in enteroendocrine cells), and the brain circuitry involved in the sensory processing of sweet taste. Complications in the use of rodents to model human sweet taste perception and responses are also considered. In addition, information relating to low-calorie sweeteners (LCS) is discussed in the context of these issues. Particular consideration is given to the known effects of LCS on enteroendocrine cell function. J. Nutr. 142: 1134S-1141S, 2012.
引用
收藏
页码：1134S / 1141S
页数：8
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