Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

被引：50

作者：

Bar, Christian ^{[1
,2
]}

Chatterjee, Shambhabi ^{[1
,2
]}

Pires, Ines Falcao ^{[3
]}

Rodrigues, Patricia ^{[3
]}

Sluijter, Joost P. G. ^{[4
]}

Boon, Reinier A. ^{[5
,6
,7
]}

Nevado, Rosa M. ^{[8
,9
]}

Andres, Vicente ^{[8
,9
]}

Sansonetti, Marida ^{[1
,2
,10
,11
]}

de Windt, Leon ^{[10
,11
]}

Ciccarelli, Michele ^{[12
]}

Hamdani, Nazha ^{[13
,14
]}

Heymans, Stephane ^{[15
,16
,17
]}

Videira, Raquel Figuinha ^{[3
,10
,11
]}

Tocchetti, Carlo G. ^{[18
]}

Giacca, Mauro ^{[19
,20
,21
]}

Zacchigna, Serena ^{[19
,21
]}

Engelhardt, Stefan ^{[22
,23
]}

Dimmeler, Stefanie ^{[24
,25
,26
]}

Madonna, Rosalinda ^{[27
]}

Thum, Thomas ^{[1
,2
]}

机构：

[1] Hannover Med Sch, Inst Mol & Translat Therapeut Strategies IMTTS, Hannover, Germany

[2] Hannover Med Sch, REBIRTH Ctr Translat Regenerat Med, Hannover, Germany

[3] Univ Porto, Fac Med, Cardiovasc Res & Dev Ctr, Porto, Portugal

[4] Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Regenerat Med Ctr, Expt Cardiol Lab, Utrecht, Netherlands

[5] Vrije Univ Amsterdam Med Ctr, Dept Physiol, Amsterdam UMC, Amsterdam Cardiovasc Sci ACS, Amsterdam, Netherlands

[6] Goethe Univ, Ctr Mol Med, Inst Cardiovasc Regenerat, Frankfurt, Germany

[7] German Ctr Cardiovasc Res DZHK, Partner Site Rhein Main, Frankfurt, Germany

[8] Ctr Nacl Invest Cardiovasc CNIC, Madrid, Spain

[9] Maastricht Univ, Fac Sci & Engn, Dept Mol Genet, Maastricht, Netherlands

[10] Maastricht Univ, Fac Hlth Med & Life Sci, CARIM Sch Cardiovasc Dis, Dept Cardiol, Maastricht, Netherlands

[11] Univ Salerno, Dept Med Surg & Dent, Fisciano, Italy

[12] Ruhr Univ Bochum, Dept Mol & Expt Cardiol, Bochum, Germany

[13] Ruhr Univ Bochum, Dept Cardiol, St Josef Hosp, Bochum, Germany

[14] Maastricht Univ, Univ Hosp Maastricht, Dept Cardiol, Med Ctr, Maastricht, Netherlands

[15] Univ Hosp Maastricht, Ctr Heart Failure Res, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands

[16] Univ Naples Federico II, Dept Translat Med Sci, Naples, Italy

[17] Univ Naples Federico II, Interdept Ctr Clin & Translat Res CIRCET, Naples, Italy

[18] Int Ctr Genet Engn & Biotechnol ICGEB, Trieste, Italy

[19] Kings Coll London, Sch Cardiovasc Med & Sci, London, England

[20] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[21] Tech Univ Munich, Inst Pharmacol & Toxicol, Biedersteiner Str 29, D-80802 Munich, Germany

[22] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Biedersteiner Str 29, D-80802 Munich, Germany

[23] Goethe Univ, Inst Cardiovasc Regenerat, Frankfurt, Germany

[24] German Ctr Cardiovasc Res DZHK, Frankfurt, Germany

[25] Cardiopulm Inst CPI, Frankfurt, Germany

[26] Univ Pisa, Inst Cardiol, Pisa, Italy

[27] Univ Texas Houston, Sch Med, Dept Internal Med, Houston, TX USA

来源：

CARDIOVASCULAR RESEARCH | 2020年 / 116卷 / 11期

基金：

欧洲研究理事会;

关键词：

Cardiovascular disease; Non-coding RNA; MicroRNA; Remodelling; Regeneration; Aging; Non-coding RNA therapy; DOXORUBICIN-INDUCED CARDIOTOXICITY; CARDIAC RESYNCHRONIZATION THERAPY; CARDIOMYOCYTE PROLIFERATION; ENDOTHELIAL-CELLS; CIRCULATING MICRORNAS; INFLAMMATORY RESPONSE; NATRIURETIC-PEPTIDE; VENTRICULAR FAILURE; EXOSOMAL TRANSFER; IN-VITRO;

D O I：

10.1093/cvr/cvaa195

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system.

引用

页码：1805 / 1819

页数：15

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