SINGLET OXYGEN DETECTION DURING PHOTOSENSITIZATION

被引：25

作者：

Li, Buhong ^{[1
]}

Lin, Huiyun ^{[1
]}

Chen, Defu ^{[2
]}

Wilson, Brian C. ^{[3
]}

Gu, Ying ^{[2
]}

机构：

[1] Fujian Normal Univ, Fujian Prov Key Lab Photon Technol, Minist Educ, Key Lab OptoElect Sci & Technol Med, Fuzhou 350007, Fujian, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China

[3] Univ Toronto, Ontario Canc Inst, Dept Med Biophys, Toronto, ON M5G 2M9, Canada

来源：

JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES | 2013年 / 6卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Photodynamic therapy; photosensitization; singlet oxygen; detection; probe; luminescence; PHOTODYNAMIC THERAPY; LUMINESCENCE; SYSTEM; PROBE; UVA;

D O I：

10.1142/S1793545813300024

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Singlet oxygen (O-1(2)) is a highly reactive oxygen species involved in numerous chemical and photochemical reactions in different biological systems and in particular, in photodynamic therapy (PDT). However, the quantification of O-1(2) generation during in vitro and in vivo photosensitization is still technically challenging. To address this problem, indirect and direct methods for O-1(2) detection have been intensively studied. This review presents the available methods currently in use or under development for detecting and quantifying O-1(2) generation during photosensitization. The advantages and limitations of each method will be presented. Moreover, the future trends in developing PDT-O-1(2) dosimetry will be briefly discussed.

引用

页数：9

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