A chemiluminescence imaging array for the detection of cancer cells by dual-aptamer recognition and bio-bar-code nanoprobe-based rolling circle amplification

被引：84

作者：

Bi, Sai ^{[1
]}

Ji, Bin ^{[1
]}

Zhang, Zhipeng ^{[1
]}

Zhang, Shusheng ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Minist Educ, Key Lab Biochem Anal, Qingdao 266042, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 33期

基金：

美国国家科学基金会;

关键词：

DNA; IMMUNOASSAY; SELEX;

D O I：

10.1039/c3cc39296a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chemiluminescence imaging array was developed for Ramos cell detection by employing a HRP-labeled bio-bar-code AuNP probe to amplify signals and dual-aptamer recognition to improve specificity, achieving high throughput, easy operation, rapid analysis, and high sensitivity for cancer cells.

引用

收藏

页码：3452 / 3454

页数：3

相关论文

共 20 条

[1] Theranostic Nanoshells: From Probe Design to Imaging and Treatment of Cancer [J].

Bardhan, Rizia ;

Lal, Surbhi ;

Joshi, Amit ;

Halas, Naomi J. .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :936-946

[2] Bio-bar-code dendrimer-like DNA as signal amplifier for cancerous cells assay using ruthenium nanoparticle-based ultrasensitive chemiluminescence detection [J].

Bi, Sai ;

Hao, Shuangyuan ;

Li, Li ;

Zhang, Shusheng .

CHEMICAL COMMUNICATIONS, 2010, 46 (33) :6093-6095

[3] Bio-bar-code functionalized magnetic nanoparticle label for ultrasensitive flow injection chemiluminescence detection of DNA hybridization [J].

Bi, Sai ;

Zhou, Hong ;

Zhang, Shusheng .

CHEMICAL COMMUNICATIONS, 2009, (37) :5567-5569

[4] Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood [J].

Chang, YS ;

di Tomaso, E ;

McDonald, DM ;

Jones, R ;

Jain, RK ;

Munn, LL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) :14608-14613

[5] Circulating Tumor Cells as Biomarkers in Prostate Cancer [J].

Danila, Daniel C. ;

Fleisher, Martin ;

Scher, Howard I. .

CLINICAL CANCER RESEARCH, 2011, 17 (12) :3903-3912

[6] Aptamers Generated from Cell-SELEX for Molecular Medicine: A Chemical Biology Approach [J].

Fang, Xiaohong ;

Tan, Weihong .

ACCOUNTS OF CHEMICAL RESEARCH, 2010, 43 (01) :48-57

[7] Chemiluminescence-Generating Nanoreactor Formulation for Near-Infrared Imaging of Hydrogen Peroxide and Glucose Level in vivo [J].

Lim, Chang-Keun ;

Lee, Yong-Deok ;

Na, Jinhee ;

Oh, Jung Min ;

Her, Song ;

Kim, Kwangmeyung ;

Choi, Kuiwon ;

Kim, Sehoon ;

Kwon, Ick Chan .

ADVANCED FUNCTIONAL MATERIALS, 2010, 20 (16) :2644-2648

[8] Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins [J].

Nam, JM ;

Thaxton, CS ;

Mirkin, CA .

SCIENCE, 2003, 301 (5641) :1884-1886

[9]

Schaferling M, 2012, ANGEW CHEM INT EDIT, V51, P2

[10] Complex target SELEX [J].

Shamah, Steven M. ;

Healy, Judith M. ;

Cload, Sharon T. .

ACCOUNTS OF CHEMICAL RESEARCH, 2008, 41 (01) :130-138