Modular Synthesis of Quinazolinone-Fused Phenanthridinones by a Palladium-Catalyzed Cascade C-H/N-H Arylation Process

被引：15
作者：
Yu, Yanhan [1 ]
Yue, Yixia [1 ]
Wang, Deqiang [1 ]
Li, Xue [1 ]
Chen, Chunxia [1 ]
Peng, Jinsong [1 ]
机构：
[1] Northeast Forestry Univ, Coll Sci, Dept Chem & Chem Engn, Harbin 150040, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2016年 / 48卷 / 22期
基金：
中国国家自然科学基金;
关键词：
palladium; C-H arylation; amidation; tandem reactions; ring-fused quinazolinones; DOMINO SYNTHESIS; BOND FORMATION; AMINATION; 2-ARYLBENZIMIDAZOLES; CHEMISTRY; BROMIDES;
D O I：
10.1055/s-0035-1561481
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient palladium-catalyzed protocol for the tandem synthesis of quinazolinone-fused phenanthridinones from 2-aryl-quinazolinones and o-dihaloarenes is described. This reaction sequence comprises direct intermolecular C-H arylation of 2-arylquinazolinones followed by an intramolecular aryl amidation reaction, affording 14Hquinazolino[3,2-f] phenanthridin-14-one derivatives in moderate to good yields.
引用
收藏
页码：3941 / 3950
页数：10
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