Effectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates: a systematic review and meta-analysis

被引：22

作者：

Bernardo, Wanderley Marques ^{[1
,2
,3
]}

Aires, Felipe Toyama ^{[4
]}

Carneiro, Renata Mota ^{[4
]}

de Sa, Fernando Pereira ^{[4
,5
]}

Vagnozzi Rullo, Vera Esteves ^{[4
,6
]}

Burns, Dennis Alexander ^{[7
,8
]}

机构：

[1] Assoc Med Brasileira, Santos, SP, Brazil

[2] Conselho Fed Med, Santos, SP, Brazil

[3] Fac Ciencias Med Santos UNILUS, Santos, SP, Brazil

[4] UNILUS, Santos, SP, Brazil

[5] Soc Brasileira Pediat, Santos, SP, Brazil

[6] Univ Fed Sao Paulo UNIFESP, Santos, SP, Brazil

[7] Soc Brasileira Pediat, Brasilia, DF, Brazil

[8] Soc Pediat Dist Fed, Brasilia, DF, Brazil

来源：

JORNAL DE PEDIATRIA | 2013年 / 89卷 / 01期

关键词：

Necrotizing enterocolitis; Probiotics; Premature; BIRTH-WEIGHT INFANTS; DOUBLE-BLIND; BIFIDOBACTERIUM-BREVE; ORAL SUPPLEMENTATION; INTESTINAL MICROBIOTA; UPDATED METAANALYSIS; PREMATURE-INFANTS; LACTOBACILLUS; PREVENTION; COLONIZATION;

D O I：

10.1016/j.jped.2013.02.004

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns. Method: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and LILACS), using a combination of the terms (necrotizing enterocolitis) AND (probiotics). Results: 11 randomized trials were included, totaling 2,887 patients, 1,431 in the probiotic group and 1,456 in the control group. There was a reduction in the incidence of NEC (NNT = 25), overall death (NNT = 34), and neonatal sepsis (NNT = 34) in the probiotic group compared to the control group. Patients that received probiotic supplementation had lower food reintroduction time (p < 0.001) and hospitalization time (p < 0.001) when compared to those not receiving probiotics. There was no difference in mortality caused by NEC. Conclusion: In premature newborns, the use of probiotics is effective as a prophylaxis for NEC and its complications. (C) 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

引用

页码：18 / 24

页数：7

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