Fatigue in multiple sclerosis - A brief review

被引：167
作者：
Induruwa, Isuru [1 ]
Constantinescu, Cris S. [1 ]
Gran, Bruno [1 ]
机构：
[1] Univ Nottingham, Queens Med Ctr, Div Clin Neurol, Nottingham NG7 2UH, England
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2012年 / 323卷 / 1-2期
关键词：
Multiple sclerosis; Fatigue; Pathophysiology; QUALITY-OF-LIFE; COGNITIVE-BEHAVIOR THERAPY; NECROSIS-FACTOR-ALPHA; OUTPATIENT REHABILITATION; CEREBROSPINAL-FLUID; SLEEP PROBLEMS; BRAIN ATROPHY; AXONAL DAMAGE; DOUBLE-BLIND; DEPRESSION;
D O I：
10.1016/j.jns.2012.08.007
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Fatigue is the most common and debilitating symptom in multiple sclerosis (MS) and is believed to be distinctly different from fatigue seen in other chronic conditions. It can affect a patient's mood, sleep and have a detrimental effect on their quality of life. In the recent years much literature has emerged in an attempt to elucidate the potential causes and treatment of this common symptom. This review article aims to examine the most recent theories on the pathophysiology of fatigue in MS as well as its association with sleep and depression. We describe the pharmacological and non-pharmacological approaches to its treatment and propose a multidisciplinary, patient enabled and individualised manner to the management of fatigue in MS. (C) 2012 Elsevier B.V. All rights reserved.
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收藏
页码：9 / 15
页数：7
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