Diazo ester insertion in N-H bonds of amino acid derivatives and insulin catalyzed by water-soluble iron and ruthenium porphyrin complexes (FeTSPPCl) as application of carbenoid transfer in aqueous media

被引：21

作者：

Srour, Hassan F. ^{[1
]}

Le Maux, Paul ^{[1
]}

Chevance, Soizic ^{[1
]}

Carrie, Daniel ^{[1
]}

Le Yondre, Nicolas ^{[2
]}

Simonneaux, Gerard ^{[1
]}

机构：

[1] Univ Rennes 1, Inst Sci Chim Rennes, UMR 6226, F-35042 Rennes, France

[2] Univ Rennes 1, CRMPO, F-35042 Rennes, France

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2015年 / 407卷

关键词：

Catalytic NH insertion; Iron porphyrin; Diazo ester; Amino ester; Insulin; RHODIUM CARBENOIDS; ETHYL DIAZOACETATE; CYCLOPROPANATION; DIAZOMETHYLPHOSPHONATE; METALLOPORPHYRINS; BIOCONJUGATION; YLIDES;

D O I：

10.1016/j.molcata.2015.06.028

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The metal complex FeTSPPCl (5,10,15,20-tetrakis)-(4-sulfonato-phenyl)-porphyrin-iron(III) chloride is an active catalyst for carbenoid insertion in N-H bonds of aminoacid derivatives in aqueous media. A variety of diazoacetates and methyl diazophosphonate were used as carbenoid precursors. The commercially available iron porphyrin complex can also selectively catalyze allcylation of the N-terminus of insulin (chain B). (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：194 / 203

页数：10

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