Long-Lived Emissive Probes for Time-Resolved Photoluminescence Bioimaging and Biosensing

被引：766

作者：

Zhang, Kenneth Yin ^{[1
,2
]}

Yu, Qi ^{[1
,2
]}

Wei, Huanjie ^{[1
,2
]}

Liu, Shujuan ^{[1
,2
]}

Zhao, Qiang ^{[1
,2
]}

Huang, Wei ^{[1
,2
,3
,4
,5
]}

机构：

[1] Nanjing Univ Posts & Telecommun, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China

[2] Nanjing Univ Posts & Telecommun, Jiangsu Key Lab Biosensors, Inst Adv Mat IAM, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China

[3] Northwestern Polytech Univ, Shaanxi Inst Flexible Elect SIFE, Xian 710072, Shaanxi, Peoples R China

[4] Nanjing Tech Univ NanjingTech, Key Lab Flexible Elect KLOFE, Nanjing 211800, Jiangsu, Peoples R China

[5] Nanjing Tech Univ NanjingTech, Inst Adv Mat IAM, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing 211800, Jiangsu, Peoples R China

来源：

CHEMICAL REVIEWS | 2018年 / 118卷 / 04期

基金：

中国国家自然科学基金;

关键词：

RESONANCE ENERGY-TRANSFER; LIFETIME IMAGING MICROSCOPY; PHOSPHORESCENT IRIDIUM(III) COMPLEXES; ACTIVATED DELAYED FLUORESCENCE; GATED LUMINESCENCE DETECTION; ROOM-TEMPERATURE PHOSPHORESCENCE; UP-CONVERSION NANOPARTICLES; SEMICONDUCTOR QUANTUM DOTS; INFRARED PERSISTENT LUMINESCENCE; LANTHANIDE-DOPED NANOPARTICLES;

D O I：

10.1021/acs.chemrev.7b00425

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this Review article, we systematically summarize the design and applications of various kinds of long-lived emissive probes for bioimaging and biosensing via time-resolved photoluminescence techniques. The probes reviewed, including lanthanides, transition-metal complexes, organic dyes, carbon and silicon nanoparticles, metal clusters, and persistent phosphores, exhibit longer luminescence lifetimes than that of autofluorescence from biological tissue and organs. When these probes are internalized into living cells or animals, time-gated photoluminescence imaging selectively collects long-lived signals for intensity analysis, while photoluminescence lifetime imaging reports the decay details of each pixel. Since the long-lived signals are differentiated from autofluorescence in the time domain, the imaging contrast and sensing sensitivity are remarkably improved. The future prospects and challenges in this rapidly growing field are addressed.

引用

页码：1770 / 1839

页数：70

共 646 条

[1] The visible human project [J].