Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease

被引：10
作者：
Demir, Arzu Meltem [1 ]
Kuloglu, Zarife [1 ]
Yaman, Aytac [1 ]
Fitoz, Suat [2 ]
Nergizoglu, Gokhan [3 ]
Kansu, Aydan [1 ]
机构：
[1] Ankara Univ, Fac Med, Dept Pediat, Div Pediat Gastroenterol, Ankara, Turkey
[2] Ankara Univ, Fac Med, Dept Radiol, Ankara, Turkey
[3] Ankara Univ, Fac Med, Dept Nephrol, Ankara, Turkey
来源：
TURKISH JOURNAL OF PEDIATRICS | 2016年 / 58卷 / 02期
关键词：
celiac disease; children; atherosclerosis; carotid intima media thickness; pulse wave velocity; PULSE-WAVE VELOCITY; GLUTEN-FREE DIET; CARDIOVASCULAR RISK; POPULATION; MORTALITY; CHILDREN; PROFILE; EVENTS; ADULTS;
D O I：
10.24953/turkjped.2016.02.008
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The association between pediatric celiac disease (CD) and atherosclerosis is unknown. Our aim was to investigate whether pediatric CD patients have an increased risk of atherosclerosis. We evaluated the premature atherosclerosis by pulse wave velocity (PWV) and carotid intima-media thickness (cIMT). A total of 37 CD patients (20 girls, mean age 13 +/- 3.3 years) and 36 healthy age and sex matched controls were enrolled. Mean duration of CD was 47.1 +/- 32.3 months and 40.5% of patients had positive tissue transglutaminase antibody (tTg) IgA. Total cholesterol level was lower in CD (p= 0.026) and cIMT was lower in tTg IgA antibody negative CD (p= 0.030). cIMT was significantly correlated with tTg IgA antibody positivity (r= 0.336; p= 0.042). Adherence to strict gluten-free diet is associated with decreased cIMT, suggesting that gluten withdrawal seems to have a beneficial effect on premature atherosclerosis.
引用
收藏
页码：172 / 179
页数：8
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