Mitochondrial biogenesis and turnover

被引：115

作者：

Diaz, Frandsca ^{[1
]}

Moraes, Carlos T. ^{[1
,2
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA

[2] Univ Miami, Miller Sch Med, Dept Cell Biol & Anat, Miami, FL 33136 USA

来源：

CELL CALCIUM | 2008年 / 44卷 / 01期

关键词：

mitochondria; biogenesis; PGC-1; replication; transcription; turnover;

D O I：

10.1016/j.ceca.2007.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover. The mechanisms associated with these events have been intensively studied in the last 20 years and our understanding of their details is much improved. Mitochondrial biogenesis requires the participation of calcium signaling that activates a series of calcium-dependent protein kinases that in turn activate transcription factors and coactivators such as PGC-1 alpha that regulates the expression of genes coding for mitochondrial components. In addition, mitochondrial biogenesis involves the balance of mitochondrial fission-fusion. Mitochondrial malfunction or defects in any of the many pathways involved in mitochondrial biogenesis can lead to degenerative diseases and possibly play an important part in aging. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：24 / 35

页数：12

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