Starch-quercetin conjugate by radical grafting: synthesis and biological characterization

被引：49

作者：

Cirillo, Giuseppe ^{[1
]}

Puoci, Francesco ^{[1
]}

Iemma, Francesca ^{[1
]}

Curcio, Manuela ^{[1
]}

Parisi, Ortensia Ilaria ^{[1
]}

Spizzirri, Umile Gianfranco ^{[1
]}

Altimari, Ilaria ^{[1
]}

Picci, Nevio ^{[1
]}

机构：

[1] Univ Calabria, Dipartimento Sci Farmaceut, I-87036 Arcavacata Di Rende, CS, Italy

来源：

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY | 2012年 / 17卷 / 04期

关键词：

Antioxidant; biomaterial; enzyme; polymer functionalization; starch; ANTIOXIDANT CAPACITY; FERULIC ACID; POLYMERS; CHITOSAN; SYSTEM;

D O I：

10.3109/10837450.2010.546413

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel flavonoid-polysaccharide conjugate was synthesized by free radical grafting of quercetin on starch. The covalent insertion of quercetin in the polymeric chain was confirmed by FT-IR, DSC and fluorescence analyses, while an estimation of the amount of quercetin bound per g of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows improved UV stability and retains the antioxidant properties of free quercetin, such as scavenging activity towards free radicals (DPPH and peroxynitrite); inhibition of the free radical formation (peroxidation of linoleic acid) and total antioxidant activity. The conjugate also prevented drug degradation and shows potential health functionality in the treatment of Alzheimer disease, diabetes and as skin-whitening agent.

引用

页码：466 / 476

页数：11

共 47 条

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