Efficacy of the Malva sylvestris L. flowers aqueous extract for functional constipation: A placebo-controlled trial

被引：20

作者：

Elsagh, Mahin ^{[1
]}

Fartookzadeh, Mohammad Reza ^{[2
]}

Kamalinejad, Mohammad ^{[3
]}

Anushiravani, Majid ^{[4
]}

Feizi, Awat ^{[5
]}

Behbahani, Farshad Amini ^{[1
]}

Rafiei, Rahmatollah ^{[6
]}

Arjmandpour, Akbar ^{[6
]}

Adibi, Peyman ^{[7
]}

机构：

[1] Iran Univ Med Sci, Res Inst Islamic & Complementary Med, Tehran, Iran

[2] Iran Univ Med Sci, Sch Med, Dept Ophthalmol, Tehran, Iran

[3] Shaheed Beheshti Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Tehran, Iran

[4] Mashhad Univ Med Sci, Dept Tradit Med, Mashhad, Iran

[5] Isfahan Univ Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Esfahan, Iran

[6] Islamic Azad Univ, Fac Med, Dept Gastroenterol, Najafabad Branch, Najafabad, Iran

[7] Isfahan Univ Med Sci, Integrat Funct Gastroenterol Res Ctr, Gastroenterol Sect, Esfahan, Iran

来源：

COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE | 2015年 / 21卷 / 02期

关键词：

Constipation; Herbal medicine; Traditional medicine; Malva; Malvaceae; IRRITABLE-BOWEL-SYNDROME; CHRONIC IDIOPATHIC CONSTIPATION; LACTIC-ACID BACTERIA; HERBAL MEDICINE; STOOL FORM; EPIDEMIOLOGY; POPULATION; INHIBITION; MANAGEMENT; PROBIOTICS;

D O I：

10.1016/j.ctcp.2015.02.003

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Objective: To evaluate the efficacy of Malva sylvestris L. flowers extract for treatment of FC. Method: Adults with FC were allocated to receive the M. sylvestris L. flowers aqueous extract syrup (MSL, 1 g extract/day) or placebo for four weeks. Frequency of constipation symptoms and stool forms were assessed every week. Self-reported improvement was assessed after treatment. Results: Compared with placebo, more increase was observed in defecation frequency (F = 18.8, P < 0.001) and more decrease was observed in frequency of all constipation symptoms by MSL (F = 16.5 to 25.3, all P values < 0.001). Also, the MSL group experienced more reduction in frequency of hard stool forms (45.4% vs. 9.1%, P < 0.001) and reported more improvement in all symptoms (all P values < 0.01) than placebo. Conclusion: The M. sylvestris L. flowers aqueous extract is efficacious and safe for the treatment of FC in adult patients. Investigating the mechanisms of action is warranted. IRCT2014031617032N1. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：105 / 111

页数：7

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