Limited utility of number needed to treat and the polarity index for bipolar disorder to characterize treatment response

被引：9

作者：

Alphs, Larry ^{[1
]}

Berwaerts, Joris ^{[2
]}

Turkoz, Ibrahim ^{[2
]}

机构：

[1] Janssen Sci Affairs LLC, Titusville, NJ 08560 USA

[2] Janssen Res & Dev LLC, Titusville, NJ 08560 USA

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2013年 / 23卷 / 11期

关键词：

Polarity index; Number needed to treat; Bipolar disease; Limitation; MAINTENANCE TREATMENT;

D O I：

10.1016/j.euroneuro.2012.12.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The medical community increasingly supports the use of simplifying constructs or ratios to facilitate incorporation of evidence-based medicine into clinical practice such as number needed to treat (NNT) and polarity index (PI). Clinicians and teachers find them to be an appealing, easy-to remember integer that can be readily translated into clinical practice. However, serious questions have been raised with respect to the validity, reliability and value of these descriptors of response. This commentary identifies some of the specific limitations of the NNT and PI constructs when applied to treatments of bipolar disorder. (C) 2013 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：1597 / 1599

页数：3

共 12 条

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