Efflux Pump-Mediated Antibiotics Resistance: Insights from Computational Structural Biology

被引：17
|
作者：
Fischer, Nadine [1 ]
Raunest, Martin [1 ]
Schmidt, Thomas H. [1 ]
Koch, Dennis C. [1 ]
Kandt, Christian [1 ]
机构：
[1] Univ Bonn, Life & Med Sci Inst, Dept Life Sci Informat B IT, D-53113 Bonn, Germany
来源：
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES | 2014年 / 6卷 / 01期
关键词：
molecular dynamics simulation; AcrB; TolC; OprM; proton conduction; multidrug transport; access regulation; membrane protein; OUTER-MEMBRANE PROTEIN; MOLECULAR-DYNAMICS SIMULATIONS; MULTIDRUG TRANSPORTER ACRB; PROTON-TRANSFER PATHWAYS; GROUND-STATE DYNAMICS; CRYSTAL-STRUCTURE; PSEUDOMONAS-AERUGINOSA; WATER-MOLECULES; DRUG TRANSPORT; OPRM;
D O I：
10.1007/s12539-014-0191-3
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The continuous rise of bacterial resistance against formerly effective pharmaceuticals is a major challenge for biomedical research. Since the first computational studies published seven years ago the simulation-based investigation of antibiotics resistance mediated by multidrug efflux pumps of the resistance nodulation division (RND) protein super family has grown into a vivid field of research. Here we review the employment of molecular dynamics computer simulations to investigate RND efflux pumps focusing on our group's recent contributions to this field studying questions of energy conversion and substrate transport in the inner membrane antiporter AcrB in Escherichia coli as well as access regulation and gating mechanism in the outer membrane efflux ducts TolC and OprM in E. coli and Pseudomonas aeruginosa.
引用
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页码：1 / 12
页数：12
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