Effect of Fermented Red Ginseng Concentrate Intake on Stool Characteristic, Biochemical Parameters, and Gut Microbiota in Elderly Korean Women

被引：6

作者：

Lee, Songhee ^{[1
]}

Jung, Sunghee ^{[2
]}

You, Heesang ^{[3
]}

Lee, Yeongju ^{[1
]}

Park, Youngsook ^{[4
]}

Lee, Hyunkoo ^{[5
]}

Hyun, Sunghee ^{[1
,2
]}

机构：

[1] Eulji Univ, Grad Sch, Dept Biomed Lab Sci, Uijeongbu Si 11759, South Korea

[2] Eulji Univ, Dept Internal Med, Coll Med, Daejeon Si 35233, South Korea

[3] Eulji Univ, Grad Sch, Dept Senior Healthcare, Uijeongbu Si 11759, South Korea

[4] Eulji Univ, Nowon Eulji Univ Hosp, Dept Gastroenterol, Sch Med, Seoul 01830, South Korea

[5] LHK Fermentat Lab, Seongnam Si 13209, South Korea

来源：

NUTRIENTS | 2022年 / 14卷 / 09期

关键词：

bowel movements; elderly individual; fermented red ginseng concentrate; glucose; gut microbiota; CHAIN FATTY-ACIDS; FAECALIBACTERIUM-PRAUSNITZII; DIVERSITY; HEALTH; DIET; METABOLISM; PROBIOTICS;

D O I：

10.3390/nu14091693

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Fermented red ginseng (FRG) has been used as a general stimulant and herbal medicine for health promotion in Asia for thousands of years. Few studies have investigated the effects of FRG containing prebiotics on the gut microbiota. Here, 29 Korean women aged >= 50 years were administered FRG for three weeks to determine its effect on stool characteristics, biochemical parameters, and gut microbiome. Gut microbial DNA was subjected to 16S rRNA V3-V4 region sequencing to assess microbial distribution in different stages. Additionally, the stool consistency, frequency of bowel movements, and biochemical parameters of blood were evaluated. We found that FRG intake improved stool consistency and increased the frequency of bowel movements compared to before intake. Biochemical parameters such as glucose, triglyceride, cholesterol, low-density lipoprotein cholesterol, creatinine, alkaline phosphatase, and lactate dehydrogenase decreased and high-density lipoprotein cholesterol increased with FRG intake. Gut microbiome analysis revealed 20 specific bacteria after three weeks of FRG intake. Additionally, 16 pathways correlated with the 20 specific bacteria were enhanced after red ginseng intake. In conclusion, FRG promoted health in elderly women by lowering blood glucose levels and improving bowel movement frequency. The increase in bacteria observed with FRG ingestion supports these findings.

引用

页数：17

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