Current approaches to malaria vaccines

被引：27

作者：

Duffy, Patrick E. ^{[1
]}

机构：

[1] NIH, NIAID, Lab Malaria Immunol & Vaccinol, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2022年 / 70卷

基金：

美国国家卫生研究院;

关键词：

PLASMODIUM-FALCIPARUM INFECTION; SPOROZOITE VACCINE; IMMUNIZATION; EFFICACY; PARASITE; PROTECTION; ANTIBODIES; CHILDREN; BINDING; SAFETY;

D O I：

10.1016/j.mib.2022.102227

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The complex Plasmodium life cycle offers different vaccine approaches with distinct parasitological and clinical effects. The approaches and their rationales were established decades ago: vaccines targeting pre-erythrocytic (sporozoite and liver -stage) parasites prevent infection, those to blood-stage parasites reduce disease, and those to sexual-stage parasites or mosquito vector reduce transmission and eliminate malaria through herd immunity. The pre-erythrocytic RTS,S vaccine (Mosquirix, GlaskoSmithKline (GSK)), recommended by WHO in 2021, reduces clinical malaria in children. Knowledge of parasite biology, host-parasite interactions, and immune mechanisms is informing new concepts to improve on RTS,S and to target other parasite stages. This review emphasizes vaccine approaches and candidates currently in the clinic or likely to enter clinical testing soon.

引用

页数：10

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