Topiramate use in obese patients with binge eating disorder: An open study

被引:49
作者
Appolinario, JC
Fontenelle, LF
Papelbaum, M
Bueno, JR
Coutinho, W
机构
[1] Univ Fed Rio de Janeiro, Inst Psychiat, Obes & Eating Disorders Grp, Rio De Janeiro, Brazil
[2] State Inst Diabet & Endocrinol Rio De Janeiro, Rio De Janeiro, Brazil
[3] Univ Fed Rio de Janeiro, Inst Psychiat, Rio De Janeiro, Brazil
[4] Pontificia Univ Catolica Rio de Janeiro, Rio De Janeiro, Brazil
来源
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE | 2002年 / 47卷 / 03期
关键词
topiramate; binge eating disorder; BED; eating disorder; obesity;
D O I
10.1177/070674370204700309
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: To assess topiramate's efficacy and tolerability in a group of obese binge eaters with no neuropsychiatric comorbidity. Method: We consecutively selected 8 obese patients with binge eating disorder (BED) and no medical or psychiatric comorbidity from individuals seeking treatment for obesity. Treatment with topiramate at 150 mg daily was administered over a 16-week period. To assesss outcome, we employed the days with binge episodes per week (DBE), the Binge Eating Scale (BES), the Beck Depression Inventory (BDI), and body weight evaluation. Results: Of the 6 patients who completed the trial, all showed reduced binge eating. Four patients presented a total remission, and 2 had a marked reduction in binge eating frequency. The mean DBE decreased significantly from 4.3 to 1.1 (P = 0.03), as did the BES scores, which fell from 31.8 to 15.3 (P = 0.04). Moreover, there was a statistically significant weight loss (mean 4.1 kg, P = 0.04). The most frequent side effects were paresthesias, fatigue, and somnolence. Conclusion: Topiramate may be an effective and well-tolerated agent in the treatment of BED in obese patients.
引用
收藏
页码:271 / 273
页数:3
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