Magnetic resonance imaging for diagnosis of early Alzheimer's disease

被引：5

作者：

Colliot, O. ^{[1
,2
,3
,4
,5
]}

Hamelin, L. ^{[1
,2
,3
,4
,5
,6
]}

Sarazin, M. ^{[7
]}

机构：

[1] Univ Paris 06, Hop La Pitie Salpetriere, Ctr Rech, UMR S975,Inst Cerveau & Moelle Epiniere, F-75013 Paris, France

[2] Hop La Pitie Salpetriere, INSERM, U975, F-75013 Paris, France

[3] Hop La Pitie Salpetriere, CNRS, UMR 7225, F-75013 Paris, France

[4] Hop La Pitie Salpetriere, ICM, Inst Cerveau & Moelle Epiniere, F-75013 Paris, France

[5] INRIA, Ctr Paris Rocquencourt, F-78153 Le Chesnay, France

[6] Grp Hosp Pitie Salpetriere, IM2A, Dept Neurol, F-75013 Paris, France

[7] Univ Paris 05, Sorbonne Paris Cite, INSERM, UMR S894,Serv Neurol,Hop St Anne, F-75014 Paris, France

来源：

REVUE NEUROLOGIQUE | 2013年 / 169卷 / 10期

关键词：

Alzheimer's disease; Magnetic resonance imaging; Anatomical MRI; Functional MRI; Diffusion-tensor imaging; MILD COGNITIVE IMPAIRMENT; VOXEL-BASED MORPHOMETRY; BRAIN ATROPHY; DEFAULT-MODE; DEMENTIA; MRI; PROGRESSION; CORRELATE; MCI;

D O I：

10.1016/j.neurol.2013.07.013

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A major challenge for neuroimaging is to contribute to the early diagnosis of Alzheimer's disease (AD). In particular, magnetic resonance imaging (MRI) allows detecting different types of structural and functional abnormalities at an early stage of the disease. Anatomical MM is the most widely used technique and provides local and global measures of atrophy. The recent diagnostic criteria of "mild cognitive impairment due to AD" include hippocampal atrophy, which is considered a marker of neuronal injury. Advanced image analysis techniques generate automatic and reproducible measures both in the hippocampus and throughout the whole brain. Recent modalities such as diffusion-tensor imaging and resting-state functional MRI provide additional measures that could contribute to the early diagnosis but require further validation. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：724 / 728

页数：5

共 32 条

[1] The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].