Microenvironment abnormalities and lymphomagenesis: Immunological aspects

被引：18

作者：

Taylor, Joseph G. ^{[1
]}

Gribben, John G. ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts Canc Inst, London, England

来源：

SEMINARS IN CANCER BIOLOGY | 2015年 / 34卷

关键词：

Lymphomagenesis; Tumorigenesis; Microenvironment; NKG2D; Natural killer; Immunosurveillance; Cytotoxic; CD8; Regulatory; PD-1; TGF beta; IL-10; Anergy; B-CELL LYMPHOMA; NON-HODGKIN-LYMPHOMA; REGULATORY T-CELLS; TGF-BETA; SUPPRESSOR-CELLS; IN-VIVO; PROTEIN EXPRESSION; HIV-1; INFECTION; NKG2D RECEPTOR; IMMUNE EVASION;

D O I：

10.1016/j.semcancer.2015.07.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Innate and adaptive immune cells within the microenvironment identify and eliminate cells displaying signs of malignant potential. Immunosurveillance effector Natural Killer (NK) cells and Cytotoxic T Lymphocytes (CTL) identify malignant cells through germline receptors such as NKG2D and in the case of CTLs, presentation of antigen through the T cell receptor. Manipulation of immunosurveillance through altered tumor-identifying ligand expression or secretion, resistance to cytotoxicity, or compromised cytotoxic cell activity through immune tolerance mechanisms all contribute to failure of these systems to prevent cancer development. This review examines the diverse mechanisms by which alterations in the immune microenvironment can promote lymphomagenesis. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：36 / 45

页数：10

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