Factors Affecting Time to Sputum Culture Conversion in Adults with Pulmonary Tuberculosis: A Historical Cohort Study without Censored Cases

被引：28

作者：

Kanda, Rie ^{[1
]}

Nagao, Taishi ^{[1
]}

Nguyen Van Tho ^{[1
]}

Ogawa, Emiko ^{[2
]}

Murakami, Yoshitaka ^{[3
]}

Osawa, Makoto ^{[4
]}

Saika, Yoshinori ^{[5
]}

Doi, Kenji ^{[6
]}

Nakano, Yasutaka ^{[1
]}

机构：

[1] Shiga Univ Med Sci, Dept Med, Div Resp Med, Otsu, Shiga, Japan

[2] Shiga Univ Med Sci, Hlth Adm Ctr, Otsu, Shiga, Japan

[3] Shiga Univ Med Sci, Dept Med Stat, Otsu, Shiga, Japan

[4] Shiga Univ Med Sci Hosp, Div Infect Control & Prevent, Otsu, Shiga, Japan

[5] Hirakata Kohsai Hosp, Dept Radiol, Osaka, Japan

[6] Morinomiya Hosp, Dept Radiol, Osaka, Japan

来源：

PLOS ONE | 2015年 / 10卷 / 11期

关键词：

CIGARETTE-SMOKING; RELAPSE; SMEAR;

D O I：

10.1371/journal.pone.0142607

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background In patients with pulmonary tuberculosis (TB), shortening the time to sputum culture conversion is desirable to reduce the likelihood of mycobacterial transmission. A persistent positive sputum culture after 2 months of treatment is reported to be associated with the presence of cavitation and the extent of disease on chest X-ray, high colony count, diabetes mellitus, and smoking. However, little is known about factors affecting the time to sputum culture conversion. This study was conducted to evaluate factors affecting the time to sputum culture conversion throughout the course of treatment in adults with pulmonary TB. Methods This study was performed using a database of the medical records of patients with active pulmonary TB who were treated at Hirakata Kohsai Hospital in Hirakata City, Osaka, Japan, from October 2000 to October 2002. Cox proportional-hazards analysis was used to evaluate factors affecting the time to sputum culture conversion after adjusting for potential confounders. Results The data of 86 patients with pulmonary TB were analyzed. The median time to sputum culture conversion was 39 days, and the maximum time was 116 days. The Cox proportional-hazards analysis showed that a higher smear grading (HR, 0.40; 95% CI, 0.23-0.71) and a history of ever smoking (HR, 0.48; 95% CI, 0.25-0.94) were associated with delayed sputum culture conversion. Conclusion High smear grading and smoking prolonged the time to sputum culture conversion in adults with pulmonary TB. To effectively control TB, measures to decrease the cigarette smoking rate should be implemented, in addition to early detection and timely anti-TB treatment.

引用

页数：9

共 16 条

[1] Predictors of delayed sputum smear and culture conversion among a Portuguese population with pulmonary tuberculosis [J].

Caetano Mota, P. ;

Carvalho, A. ;

Valente, I. ;

Braga, R. ;

Duarte, R. .

REVISTA PORTUGUESA DE PNEUMOLOGIA, 2012, 18 (02) :72-79

[2] Delayed culture conversion due to cigarette smoking in active pulmonary tuberculosis patients [J].

de Boer, Renee Nijenbandring ;

de Oliveira e Souza Filho, Joao Baptista ;

Cobelens, Frank ;

Ramalho, Daniela de Paula ;

Campino Miranda, Pryscilla Fernandes ;

de Logo, Karina ;

Oliveira, Hedi ;

Mesquita, Eliene ;

Oliveira, Martha Maria ;

Kritski, Afranio .

TUBERCULOSIS, 2014, 94 (01) :87-91

[3] Diagnostic standards and classification of tuberculosis in adults and children [J].

Dunlap, NE ;

Bass, J ;

Fujiwara, P ;

Hopewell, P ;

Horsburgh, CR ;

Salfinger, M ;

Simone, PM .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 161 (04) :1376-1395

[4] Factors influencing sputum smear and culture conversion time among patients with new case pulmonary tuberculosis [J].

Gueler, M. ;

Uensal, E. ;

Dursun, B. ;

Aydin, Oe. ;

Capan, N. .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2007, 61 (02) :231-235

[5] Smoking adversely affects treatment response, outcome and relapse in tuberculosis [J].

Leung, Chi C. ;

Yew, Wing W. ;

Chan, Chi K. ;

Chang, Kwok C. ;

Law, Wing S. ;

Lee, Shuk N. ;

Tai, Lai B. ;

Leung, Eric C. C. ;

Au, Ronald K. F. ;

Huang, Shan S. ;

Tam, Cheuk M. .

EUROPEAN RESPIRATORY JOURNAL, 2015, 45 (03) :738-745

[6] Smoking and 2-month culture conversion during anti-tuberculosis treatment [J].

Maciel, E. L. ;

Brioschi, A. P. ;

Peres, R. L. ;

Guidoni, L. M. ;

Ribeiro, F. K. ;

Hadad, D. J. ;

Vinhas, S. A. ;

Zandonade, E. ;

Palaci, M. ;

Dietze, R. ;

Johnson, J. L. .

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2013, 17 (02) :225-228

[7] ASSESSMENT OF NEW STERILIZING DRUGS FOR TREATING PULMONARY TUBERCULOSIS BY CULTURE AT 2 MONTHS [J].

MITCHISON, DA .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (04) :1062-1063

[8] Cigarette Smoking Impairs Human Pulmonary Immunity to Mycobacterium tuberculosis [J].

O'Leary, Seonadh M. ;

Coleman, Michelle M. ;

Chew, Wui Mel ;

Morrow, Colette ;

McLaughlin, Anne Marie ;

Gleeson, Laura E. ;

O'Sullivan, Mary P. ;

Keane, Joseph .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 190 (12) :1430-1436

[9] Continuous and Discontinuous Cigarette Smoke Exposure Differentially Affects Protective Th1 Immunity against Pulmonary Tuberculosis [J].

Shaler, Christopher R. ;

Horvath, Carly N. ;

McCormick, Sarah ;

Jeyanathan, Mangalakumari ;

Khera, Amandeep ;

Zganiacz, Anna ;

Kasinska, Joanna ;

Stampfli, Martin R. ;

Xing, Zhou .

PLOS ONE, 2013, 8 (03)

[10] Cigarette Smoke Increases Susceptibility to Tuberculosis-Evidence From In Vivo and In Vitro Models [J].

Shang, Shaobin ;

Ordway, Diane ;

Henao-Tamayo, Marcela ;

Bai, Xiyuan ;

Oberley-Deegan, Rebecca ;

Shanley, Crystal ;

Orme, Ian M. ;

Case, Stephanie ;

Minor, Maisha ;

Ackart, David ;

Hascall-Dove, Laurel ;

Ovrutsky, Alida R. ;

Kandasamy, Pitchaimani ;

Voelker, Dennis R. ;

Lambert, Cherie ;

Freed, Brian M. ;

Iseman, Michael D. ;

Basaraba, Randall J. ;

Chan, Edward D. .

JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (09) :1240-1248

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