Effects of phytosterols supplementation on blood pressure: A systematic review and meta-analysis

被引：27

作者：

Ghaedi, Ehsan ^{[1
,2
]}

Foshati, Sahar ^{[3
]}

Ziaei, Rahele ^{[3
]}

Beigrezaei, Sara ^{[4
]}

Kord-Varkaneh, Hamed ^{[5
]}

Ghavami, Abed ^{[3
]}

Miraghajani, Maryam ^{[6
,7
]}

机构：

[1] Univ Tehran Med Sci, Students Sci Res Ctr SSRC, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran

[3] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Food Secur Res Ctr, Esfahan, Iran

[4] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Nutr & Food Secur Res Ctr, Yazd, Iran

[5] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Student Res Comm, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran

[7] Univ Nottingham, Div Child Hlth Obstet & Gynaecol, Early Life Res Unit, Nottingham, England

来源：

CLINICAL NUTRITION | 2020年 / 39卷 / 09期

关键词：

Phytosterol; Blood pressure; Systematic review; Meta-analysis; SERUM-CHOLESTEROL CONCENTRATION; LOW-FAT MILK; PLANT STEROLS; METABOLIC SYNDROME; SAFETY EVALUATION; DIETARY PHYTOSTEROLS; ENDOTHELIAL FUNCTION; ADULTS; ABSORPTION; HYPERTENSION;

D O I：

10.1016/j.clnu.2019.12.020

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Several reports have indicated a positive effect of phytosterols on blood pressure (BP), nevertheless these findings have been controversial. Therefore, a systematic review and meta-analysis of randomized controlled trials (RCTs) was aimed to investigate the effects of phytosterol supplementation on BP. An online search was carried out in PubMed, Scopus, ISI Web of Science, Cochrane library and Google Scholar up to May 2019. Weighted Mean difference (WMD) with 95% confidence intervals (CIs) were calculated using a fixed-effects model. The present meta-analysis of 19 RCTs showed that supplementation with phytosterols can decrease both systolic BP (WMD:-1.55 mmHg, 95% CI:-2.67 to-0.42, p = 0.007) and diastolic BP (WMD:-0.84 mmHg, 95% CI:-1.60 to-0.08, p = 0.03). Dose-response analysis revealed that phytosterol intake change SBP significantly based on treatment dose in nonlinear fashion. Subgroup analysis based on duration showed a significant effect of phytosterol on SBP and DBP in subsets of 12 weeks. In addition, a significant effect of phytosterol was observed in dosage of 2000 mg for SBP and <2000 mg for DBP. Based on current findings supplementation with phytosterol may be a beneficial adjuvant therapy in hypertensive patients as well as a complementary preventive option in prehypertensive and normotensive individuals. However, this issue is still open and requires further investigation in future studies. (c) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

引用

页码：2702 / 2710

页数：9

共 78 条

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