Hydrolytically stable octahedral silicon complexes as bioactive scaffolds: application to the design of DNA intercalators

被引：19

作者：

Xiang, Yonggang ^{[1
]}

Fu, Chen ^{[1
]}

Breiding, Tom ^{[1
]}

Sasmal, Pijus K. ^{[1
]}

Liu, Haidong ^{[2
]}

Shen, Qi ^{[2
]}

Harms, Klaus ^{[1
]}

Zhang, Lilu ^{[1
]}

Meggers, Eric ^{[1
,3
]}

机构：

[1] Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany

[2] Soochow Univ, Coll Chem & Chem Engn, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[3] Xiamen Univ, Coll Chem & Chem Engn, Dept Biol Chem, Xiamen 361005, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 57期

关键词：

HALOSILANE ADDUCTS; STRUCTURAL-CHARACTERIZATION; METAL-COMPLEXES; CHEMISTRY; LIGANDS; REACTIVITY; SKELETONS; ACIDS;

D O I：

10.1039/c2cc32506c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We here introduce octahedral silicon serving as a structural center for the design of hydrolytically stable bioactive complexes as demonstrated with the generation of silicon-based high affinity DNA binders. This proof-of-principle study suggests that octahedral silicon complexes are falsely neglected, promising structural templates for widespread applications in chemical biology and medicinal chemistry.

引用

页码：7131 / 7133

页数：3

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