The impact of CMV infection on survival in older humans

被引：89
作者：
Pawelec, Graham [1 ]
McElhaney, Janet E. [2 ]
Aiello, Allison E. [3 ]
Derhovanessian, Evelyna [1 ]
机构：
[1] Univ Tubingen, Sch Clin, Tubingen Ageing & Tumour Immunol Grp, Med Res Ctr, D-72072 Tubingen, Germany
[2] Univ British Columbia, Dept Med, Vancouver, BC, Canada
[3] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 04期
基金：
美国国家卫生研究院; 欧盟第七框架计划; 加拿大健康研究院;
关键词：
T-CELL RESPONSES; CYTOMEGALOVIRUS-INFECTION; INFLUENZA VACCINATION; IMMUNE-SYSTEM; PROTECTION; MORTALITY; ANTIBODY; IMMUNOSENESCENCE; FRAILTY; RISK;
D O I：
10.1016/j.coi.2012.04.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dysregulated immunity, 'immunosenescence', in the elderly is thought to contribute to their increased susceptibility to infectious disease and to impact on mortality. Accepted hallmarks of human immunosenescence are low numbers and frequencies of naive T cells and higher numbers and frequencies of memory T cells in the peripheral blood of the elderly compared to the young. The proportion of the population infected with CMV increases with age and markedly influences these parameters. Infection with this persistent beta-herpesvirus may therefore indirectly impact on survival in the elderly. Recent evidence pertaining to this controversial proposal is reviewed here.
引用
收藏
页码：507 / 511
页数：5
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