Paving the way for successful islet encapsulation

被引：44

作者：

Dimitrioglou, Nikos ^{[1
]}

Kanelli, Maria ^{[1
]}

Papageorgiou, Efstathia ^{[2
]}

Karatzas, Theodore ^{[3
]}

Hatziavramidis, Dimitris ^{[1
]}

机构：

[1] Natl Tech Univ Athens, Sch Chem Engn, Zografou Campus, Athens 15780, Greece

[2] Univ Athens, Dept Med, Athens 11527, Greece

[3] Univ Athens, Sch Med, Dept Propaedeut Surg 2, GR-11527 Athens, Greece

来源：

DRUG DISCOVERY TODAY | 2019年 / 24卷 / 03期

关键词：

MESENCHYMAL STEM-CELLS; BETA-CELLS; PANCREATIC-ISLETS; PIG ISLETS; ALGINATE; TRANSPLANTATION; DEVICE; HYDROGEL; XENOTRANSPLANTATION; SCAFFOLDS;

D O I：

10.1016/j.drudis.2019.01.020

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Type 1 diabetes mellitus (T1DM) is a disorder that decimates pancreatic beta-cells which produce insulin. Direct pancreatic islet transplantation cannot serve as a widespread therapeutic modality owing to the need for lifelong immunosuppression and donor shortage. Therefore, several encapsulation techniques have been developed to enclose the islets in semipermeable vehicles that will allow oxygen and nutrient input as well as insulin, other metabolites and waste output, while accomplishing immunoisolation. Although encapsulation technology continues to face significant obstacles, recent advances in material science, stem cell biology and immunology potentially serve as pathways to success. This review summarizes the accomplishments of the past 5 years.

引用

页码：737 / 748

页数：12

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