Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza

被引：91

作者：

Shoji, Yoko ^{[1
]}

Bi, Hong ^{[1
]}

Musiychuk, Konstantin ^{[1
]}

Rhee, Amy ^{[1
]}

Horsey, April ^{[1
]}

Roy, Gourgopal ^{[1
]}

Green, Brian ^{[1
]}

Shamloul, Moneim ^{[1
]}

Farrance, Christine E. ^{[1
]}

Taggart, Barbara ^{[2
]}

Mytle, Nutan ^{[2
]}

Ugulava, Natalia ^{[1
]}

Rabindran, Shailaja ^{[1
]}

Mett, Vadim ^{[1
]}

Chichester, Jessica A. ^{[1
]}

Yusibov, Vidadi ^{[1
]}

机构：

[1] Fraunhofer USA Ctr Mol Biotechnol, Newark, DE 19711 USA

[2] So Res Inst, Birmingham, AL 35355 USA

来源：

VACCINE | 2009年 / 27卷 / 07期

关键词：

Highly pathogenic avian influenza; Hemagglutinin; Plant-derived vaccine; RANDOMIZED CONTROLLED-TRIAL; CROSS-REACTIVE IMMUNITY; PANDEMIC INFLUENZA; RECOMBINANT PROTEIN; VACCINE CANDIDATE; VIRAL VECTORS; H5N1; VACCINE; VIRUS; IMMUNOGENICITY; EXPRESSION;

D O I：

10.1016/j.vaccine.2008.11.108

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The global spread of highly pathogenic avian influenza virus (H5N1 subtype) has promoted efforts to develop human vaccines against potential pandemic outbreaks. However, current platforms for influenza vaccine production are cumbersome, limited in scalability and often require the handling of live infectious virus. We describe the production of hemagglutinin from the A/Indonesia/05/05 strain of H5N1 influenza virus by transient expression in plants, and demonstrate the immunogenicity and protective efficacy of the vaccine candidate in animal models. Immunization of mice and ferrets with plant-derived hemagglutinin elicited serum hemagglutinin-inhibiting antibodies and protected the ferrets against challenge infection with a homologous virus. This demonstrates that plant-derived H5 HA is immunogenic in mice and ferrets, and can induce protective immunity against infection with highly pathogenic avian influenza virus. Plants could therefore be Suitable as a platform for the rapid, large-scale production of influenza vaccines in the face of a pandemic. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1087 / 1092

页数：6

共 35 条

[1]

Audsley JM, 2004, EXPERT OPIN BIOL TH, V4, P709, DOI 10.1517/14712598.4.5.709

[2] Cross-Protection against Lethal H5N1 Challenge in Ferrets with an Adjuvanted Pandemic Influenza Vaccine [J].

Baras, Benoit ;

Stittelaar, Koert J. ;

Simon, James H. ;

Thoolen, Robert J. M. M. ;

Mossman, Sally P. ;

Pistoor, Frank H. M. ;

van Amerongen, Geert ;

Wettendorff, Martine A. ;

Hanon, Emmanuel ;

Osterhaus, Albert D. M. E. .

PLOS ONE, 2008, 3 (01)

[3] Safety and immunogenicity of an inactivated split-virion influenza A/Vietnam/1194/2004 (H5N1) vaccine:: phase I randomised trial [J].

Bresson, Jean-Louis ;

Perronne, Christian ;

Launay, Odile ;

Gerdil, Catherine ;

Saville, Melanie ;

Wood, John ;

Hoeschler, Katja ;

Zambon, Maria C. .

LANCET, 2006, 367 (9523) :1657-1664

[4] Cross-Clade Protective Immune Responses to Influenza Viruses with H5N1 HA and NA Elicited by an Influenza Virus-Like Particle [J].

Bright, Rick A. ;

Carter, Donald M. ;

Crevar, Corey J. ;

Toapanta, Franklin R. ;

Steckbeck, Jonathan D. ;

Cole, Kelly S. ;

Kumar, Niranjan M. ;

Pushko, Peter ;

Smith, Gale ;

Tumpey, Terrence M. ;

Ross, Ted M. .

PLOS ONE, 2008, 3 (01)

[5] Use of viral vectors for vaccine production in plants [J].

Cañizares, MC ;

Nicholson, L ;

Lomonossoff, GP .

IMMUNOLOGY AND CELL BIOLOGY, 2005, 83 (03) :263-270

[6] Immunogenicity of a subunit vaccine against Bacillus anthracis [J].

Chichester, Jessica A. ;

Musiychuk, Konstantin ;

de la Rosa, Patricia ;

Horsey, April ;

Stevenson, Natalie ;

Ugulava, Natalia ;

Rabindran, Shailaja ;

Palmer, Gene A. ;

Mett, Vadim ;

Yusibov, Vidadi .

VACCINE, 2007, 25 (16) :3111-3114

[7] HOST CELL-MEDIATED SELECTION OF A MUTANT INFLUENZA A VIRUS THAT HAS LOST A COMPLEX OLIGOSACCHARIDE FROM THE TIP OF THE HEMAGGLUTININ [J].

DEOM, CM ;

CATON, AJ ;

SCHULZE, IT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (11) :3771-3775

[8] Viral vectors for the expression of proteins in plants [J].

Gleba, Yuri ;

Klimyuk, Victor ;

Marillonnet, Sylvestre .

CURRENT OPINION IN BIOTECHNOLOGY, 2007, 18 (02) :134-141

[9] Transient protein expression in three Pisum sativum (green pea) varieties [J].

Fraunhofer USA Center for Molecular Biotechnology, 9 Innovation Way, Newark, DE 19711, United States .

Biotechnol. J., 2009, 2 (230-237) :230-237

[10] Phase I, Randomized, Controlled Trial to Study the Reactogenicity and Immunogenicity of a Nasal, Inactivated Trivalent Influenza Virus Vaccine in Healthy Adults [J].

Halperin, Scott A. ;

Smith, Bruce ;

Clarke, Kevin ;

Treanor, John ;

Mabrouk, Taoufik ;

Germain, Marc .

HUMAN VACCINES, 2005, 1 (01) :37-42

← 1 2 3 4 →