IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

被引：170

作者：

Barone, Francesca ^{[1
,2
]}

Nayar, Saba ^{[1
,2
]}

Campos, Joana ^{[1
,2
]}

Cloake, Thomas ^{[1
,2
]}

Withers, David R. ^{[3
]}

Toellner, Kai-Michael ^{[3
]}

Zhang, Yang ^{[3
]}

Fouser, Lynette ^{[4
]}

Fisher, Benjamin ^{[1
,2
]}

Bowman, Simon ^{[1
,2
]}

Rangel-Moreno, Javier ^{[5
]}

Garcia-Hernandez, Maria de la Luz ^{[5
]}

Randall, Troy D. ^{[6
]}

Lucchesi, Davide ^{[7
]}

Bombardieri, Michele ^{[7
]}

Pitzalis, Costantino ^{[7
]}

Luther, Sanjiv A. ^{[8
]}

Buckley, Christopher D. ^{[1
,2
]}

机构：

[1] Univ Birmingham, Coll Med & Dent Sci, Sch Immun & Infect, Rheumatol Res Grp,Ctr Translat Inflammat Res, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Res Labs, Queen Elizabeth Hosp, Birmingham B15 2WD, W Midlands, England

[3] Univ Birmingham, Coll Med & Dent Sci, Sch Infect & Immun, Birmingham B15 2TT, W Midlands, England

[4] Pfizer Res, Cambridge, MA 02139 USA

[5] Univ Rochester, Dept Med, Div Allergy Immunol & Rheumatol, Rochester, NY 14642 USA

[6] Univ Alabama Birmingham, Dept Med, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA

[7] Queen Mary Univ London, Ctr Expt Med & Rheumatol, London EC1M 6BQ, England

[8] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2015年 / 112卷 / 35期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

IL-22; tertiary lymphoid organs; chemokines; Sjogren's syndrome; autoimmunity; SJOGRENS-SYNDROME; RHEUMATOID-ARTHRITIS; B-CELLS; BARRIER SURFACES; SALIVARY-GLANDS; MALT LYMPHOMA; STROMAL CELLS; MOUSE MODEL; LIGHT ZONE; T-CELLS;

D O I：

10.1073/pnas.1503315112

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The series of events leading to tertiary lymphoid organ (TLO) formation in mucosal organs following tissue damage remain unclear. Using a virus-induced model of autoantibody formation in the salivary glands of adult mice, we demonstrate that IL-22 provides a mechanistic link between mucosal infection, B-cell recruitment, and humoral autoimmunity. IL-22 receptor engagement is necessary and sufficient to promote differential expression of chemokine (C-X-C motif) ligand 12 and chemokine (C-X-C motif) ligand 13 in epithelial and fibroblastic stromal cells that, in turn, is pivotal for B-cell recruitment and organization of the TLOs. Accordingly, genetic and therapeutic blockade of IL-22 impairs and reverses TLO formation and autoantibody production. Our work highlights a critical role for IL-22 in TLO-induced pathology and provides a rationale for the use of IL-22-blocking agents in B-cell-mediated autoimmune conditions.

引用

页码：11024 / 11029

页数：6

共 50 条

[1] IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs
Nayar, S.
Campos, J.
Cloake, T.
Bowman, S.
Bombardieri, M.
Pitzalis, C.
Luther, S.
Buckley, C.
Barone, F.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2015, 81 (05) : 425 - 425
[2] IL22 REGULATES AUTOANTIBODY PRODUCTION BY INDUCING LYMPHOID CHEMOKINE EXPRESSION IN TERTIARY LYMPHOID ORGANS
Nayar, S.
Campos, J.
Cloake, T.
Bowman, S.
Bombardieri, M.
Pitzalis, C.
Luther, S.
Buckley, C.
Barone, F.
ANNALS OF THE RHEUMATIC DISEASES, 2015, 74 : 651 - 651
[3] IL-22 Regulates Induction of Foxp3-Rich Tertiary Lymphoid Organs in Tolerant Lung Allografts
Tanaka, S.
Gauthier, J. M.
Fuchs, A.
Li, W.
Higashikubo, R.
Tong, A. Y.
Krupnick, A. S.
Gelman, A. E.
Kreisel, D.
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2019, 38 (04): : S40 - S40
[4] Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs
Koenig, Alice
Thaunat, Olivier
FRONTIERS IN IMMUNOLOGY, 2016, 7
[5] IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection
Baum, C.
Khattar, M.
Schroder, P.
Chen, W.
Stepkowski, S.
AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15
[6] Lyn activity protects mice from DSS colitis and regulates the production of IL-22 from innate lymphoid cells
Bishop, J. L.
Roberts, M. E.
Beer, J. L.
Huang, M.
Chehal, M. K.
Fan, X.
Fouser, L. A.
Ma, H. L.
Bacani, J. T.
Harder, K. W.
MUCOSAL IMMUNOLOGY, 2014, 7 (02) : 405 - 416
[7] Innate Lymphoid Cell-Derived IL-22 Regulates Epithelial Recovery From Gvhd
Hanash, Alan M.
Dudakov, Jarrod A.
Hua, Guoqiang
O'Connor, Margaret
Young, Lauren F.
Blazar, Bruce R.
Kolesnick, Richard
van den Brink, Marcel R. M.
BLOOD, 2012, 120 (21)
[8] Crosstalk between innate lymphoid cells and T cells enhances IL-22 production
Parigi, Sara M.
Czarnewski, Paulo
Villablanca, Eduardo J.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2017, 86 (04) : 269 - 269
[9] Chemokine-dependent development of primary, secondary and tertiary lymphoid organs
Foerster, R.
PATHOLOGY RESEARCH AND PRACTICE, 2007, 203 (05) : 341 - 342
[10] IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection.
Breidenbach, J.
Baum, C.
Schroder, P.
Stepkowski, S.
AMERICAN JOURNAL OF TRANSPLANTATION, 2018, 18 : 406 - 406

← 1 2 3 4 5 →