High resolution spatial mapping of nicotine action using pharmacologic magnetic resonance imaging

被引:17
作者
Choi, Ji-Kyung
Mandeville, Joseph B.
Chen, Y. Iris
Kim, Young R.
Jenkins, Bruce G.
机构
[1] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol, Charlestown, MA 02129 USA
[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA
关键词
rats; choline; dopamine; MRI; cerebral blood volume; hemodynamics;
D O I
10.1002/syn.20284
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Nicotine is one of the most addictive substances known. To better understand the mechanisms of action, we mapped the regional brain response to nicotine administration using pharmacologic magnetic resonance imaging (phMRI) in rats. We measured the regional response of relative cerebral blood volume (rCBV) in rats to a challenge of 0.07 mg/kg (0.43 mu mol/kg) of nicotine. The areas of the brain with significant and reproducible changes in the rCBV response were (in descending order of magnitude) infralimbic cortex, hippocampus (subiculum), agranular insular/pyriform cortex, visual cortex, interpeduncular area, nucleus accumbens, cingulate cortex, thalamus, and septum. This pattern of response is consistent with stimulation of both cholinergic and dopaminergic neuronal pathways and is consistent with the known behavioral properties of nicotine. The peak CBV response to nicotine occurred between 9 and 13 min depending upon brain region, and the average full width half-maximum of the rCBV response was 27 min. The high spatial and temporal resolution of the phMRI technique lends itself well to further, more detailed, studies of nicotine dynamics.
引用
收藏
页码:152 / 157
页数:6
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