Heat-shock protein-70 and regulatory T cell-mediated protection from ischemic injury

被引：12

作者：

O'Neill, Stephen ^{[1
]}

Hughes, Jeremy ^{[1
]}

机构：

[1] Queens Med Res Inst, Ctr Inflammat Res, MRC, Edinburgh EH16 4TJ, Midlothian, Scotland

来源：

KIDNEY INTERNATIONAL | 2014年 / 85卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ki.2013.304

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Heat preconditioning induces heat-shock protein-70 upregulation and protects from renal ischemia/reperfusion injury. Kim et al. report that heat-shock protein-70 and regulatory T cells play a key role in protective heat preconditioning. This work reinforces the utility of inducing heat-shock protein-70 expression by pharmacological agents as a novel therapy for the prevention and treatment of ischemic kidney injury.

引用

页码：5 / 7

页数：3

共 18 条

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