Prevalence of antibiotic resistance of Pseudomonas aeruginosa in cystic fibrosis infection: A systematic review and meta-analysis

被引：30

作者：

Bonyadi, Parisa ^{[1
]}

Saleh, Narjes Tehrani ^{[2
]}

Dehghani, Mohadeseh ^{[4
]}

Yamini, Mahsa ^{[3
]}

Amini, Kumarss ^{[5
]}

机构：

[1] Arak Islamic Azad Univ, Coll Biosci, Dept Microbiol, Arak, Iran

[2] Islamic Azad Univ, Ctr Tehran Branch, Dept Biomed, Tehran, Iran

[3] Islamic Azad Univ, Dept Biomed Engn, South Tehran Branch, Tehran, Iran

[4] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Microbiol, Tehran Med Sci, Tehran, Iran

[5] Islamic Azad Univ, Dept Microbiol, Saveh Branch, Saveh, Iran

来源：

MICROBIAL PATHOGENESIS | 2022年 / 165卷

关键词：

Pseudomonas aeruginosa; Antibiotic resistance; Cystic fibrosis; Meta analysis; METALLO-BETA-LACTAMASE; IN-VITRO ACTIVITY; ANTIMICROBIAL SUSCEPTIBILITY; LONG-TERM; INHALED TOBRAMYCIN; AMINOGLYCOSIDE-RESISTANCE; STAPHYLOCOCCUS-AUREUS; CROSS-INFECTION; THERAPY; STRAINS;

D O I：

10.1016/j.micpath.2022.105461

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: Pseudomonas aeruginosa is an opportunistic pathogen that infects the lungs of people with cystic fibrosis (CF) and is the most common cause of chronic respiratory infections with high morbidity and mortality in CF patients. This study aimed to evaluate the pattern of antibiotic resistance of P. aeruginosa strains from patients with CF using a systematic review and meta-analysis. Methods: A comprehensive and systematic search was performed for relevant articles until August 2021 in the following database: PubMed, Scopus, Embase, and Web of Science. Finally, 122 articles with appropriate criteria were included in the meta-analysis. To estimate weighted pooled proportions Freeman-Tukey double arcsine transformation was performed using Metaprop command in Stata software version 17.1. Results: 122 studies evaluated the pattern of P. aeruginosa antibiotic resistance from different antibiotic classes in patients with CF. Cefotaxime had the highest resistance rate of 67% (95% CI 53_80%), while colistin had the lowest 5% (95% CI 2-8%). Conclusion: High resistance to most of the studied antibiotics was observed. The high antibiotic resistance observed is worrying and it indicates the need to monitor using of antibiotics. In addition, colistin is the most appropriate treatment choice, but more randomized controlled trial studies are recommended.

引用

页数：11

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