The High Affinity CXCR4 Inhibitor, BL-8040, Induces Apoptosis of AML Blasts and Their Terminal Differentiation By Blocking AKT/ERK Survival Signals and Downregulating BCL-2, MCL-1 and Cyclin-D1 through Regulation of Mir-15a/16-1 Expression

被引：0

作者：

Abraham, Michal ^{[1
]}

Klein, Shiri ^{[2
]}

Bulvik, Baruch ^{[3
]}

Wald, Hanna ^{[3
]}

Holam, Dvora ^{[2
]}

Weiss, Lola ^{[2
]}

Beider, Katia ^{[4
]}

Eizenberg, Orly ^{[3
]}

Wald, Ori ^{[2
]}

Avigdor, Abraham ^{[5
,6
]}

Benjamini, Ohad ^{[7
]}

Galun, Eithan ^{[2
]}

Nagler, Arnon ^{[5
]}

Pereg, Yaron ^{[8
]}

Peled, Amnon ^{[2
,3
]}

机构：

[1] Biokine Therapeut Ltd, Rehovot, Israel

[2] Hebrew Univ Hosp, Goldyne Savad Inst Gene Therapy, Jerusalem, Israel

[3] Biokine Therapeut Ltd, Ness Ziona, Israel

[4] Chaim Sheba Med Ctr, Div Hematol & Bone Marrow Transplantat, Tel HaShomer, Ramat Gan, Israel

[5] Chaim Sheba Med Ctr, Div Hematol & Bone Marrow Transplantat, Tel Hashomer, Tel Aviv, Israel

[6] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel

[7] Sheba Med Ctr, Div Hematol & Bone Marrow Transplantat, Tel Hashomer, Israel

[8] BioLineRx Ltd, Modiin, Israel

来源：

关键词：

D O I：

10.1182/blood.V128.22.767.767

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

767

引用

页数：7