Antiplasmodial and cytotoxic activity of isolated sesquiterpene lactones from the acetone leaf extract of Vernonia colorata

被引：26

作者：

Chukwujekwu, J. C. ^{[1
]}

Lategan, C. A. ^{[2
]}

Smith, P. J. ^{[2
]}

Van Heerden, F. R. ^{[3
]}

Van Staden, J. ^{[1
]}

机构：

[1] Univ KwaZulu Natal Pietermaritzburg, Sch Biol & Conservat Sci, Res Ctr Plant Growth Dev, ZA-3209 Scottsville, South Africa

[2] Univ Cape Town, Div Pharmacol, Dept Med, ZA-7700 Rondebosch, South Africa

[3] Univ KwaZulu Natal Pietermaritzburg, Sch Chem, ZA-3209 Scottsville, South Africa

来源：

SOUTH AFRICAN JOURNAL OF BOTANY | 2009年 / 75卷 / 01期

基金：

英国医学研究理事会;

关键词：

Antiplasmodial; Cytotoxicity; Vernodalin; Vernolide; Vernonia colorala; MEDICINAL-PLANTS; ASSAY; AMYGDALINA; LEAVES;

D O I：

10.1016/j.sajb.2008.10.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Vernonia colorata is used throughout Africa to treat various ailments. Its antiplasmodial activity has been widely reported. Using bioassay-guided fractionation, we isolated two antiplasmodial compounds - vernolide (IC(5)0=1.87 mu g/ml) and vernodalin (IC50=0.52 mu g/ml) with selective indices of 1.02 and 2.79 for vernolide and vernodalin respectively. These compounds are non-specific towards parasites. (C) 2008 SAAB. Published by Elsevier B.V. All rights reserved.

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页码：176 / 179

页数：4

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