Rapid and Sensitive Detection of Vinorelbine in the Urine of Tumor Patients by Capillary Electrophoresis with Tris(2,2′-bipyridyl)ruthenium(II)-based Electrochemiluminescence Assay

被引：11

作者：

Zhou, Qing-Wei ^{[1
]}

Wu, Di ^{[2
]}

Meng, Qin ^{[3
]}

Tang, Hai-Bo ^{[2
]}

Wei, Zheng-Ren ^{[3
]}

Kuang, Ye ^{[3
]}

Yin, Jian-Yuan ^{[3
]}

Chen, Jia-Jun ^{[4
]}

机构：

[1] Jilin Univ, Inst Frontier Med Sci, Dept Biochem & Mol Biol, Changchun 130021, Peoples R China

[2] Jilin Prov Tumor Hosp, Tumorol Dept, Changchun 130012, Peoples R China

[3] Jilin Univ, Pharmaceut Coll, Chem Lab Tradit Chinese Med, Changchun 130021, Peoples R China

[4] Jilin Univ, China Japan Union Hosp, Dept Neurol, Changchun 130033, Peoples R China

来源：

ANALYTICAL SCIENCES | 2013年 / 29卷 / 07期

关键词：

Vinorelbine; capillary electrophoresis; electrochemiluminescence; LIQUID-CHROMATOGRAPHIC DETERMINATION; QUANTITATIVE-ANALYSIS; HUMAN PLASMA; NAVELBINE; METABOLITES; MOUSE; BLOOD; CELLS;

D O I：

10.2116/analsci.29.757

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A capillary electrophoresis method coupled with electrochemiluminescence detection for the analysis of vinorelbine (VNB) in the urine of tumor patients was established in this research. Complete determination of VNB was achieved in 8 min using a background electrolyte of 50 mmol/L phosphate buffer (pH 9.0) and a separation voltage of 15 kV. The calibration curves showed a linear range from 2.8 x 10(-10) to 1.6 x 10(-8) mol/L. The relative standard derivation for VNB was below 3.4%. The linear relationships were good and the correlation factor of VNB exceeded 0.985. The detection limits were 1.0 x 10(-11) mol/L under the optimal conditions. The developed method was applied to the sensitive determination of VNB in the urine of tumor patients.

引用

页码：757 / 760

页数：4

共 24 条

[1] Nanostructured materials for electrochemiluminescence (ECL)-based detection methods: Recent advances and future perspectives [J].

Bertoncello, Paolo ;

Forster, Robert J. .

BIOSENSORS & BIOELECTRONICS, 2009, 24 (11) :3191-3200

[2] PHARMACOKINETICS OF A NEW ANTICANCER DRUG, NAVELBINE, IN PATIENTS - COMPARATIVE-STUDY OF RADIOIMMUNOLOGIC AND RADIOACTIVE DETERMINATION METHODS [J].

BORE, P ;

RAHMANI, R ;

VANCANTFORT, J ;

FOCAN, C ;

CANO, JP .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1989, 23 (04) :247-251

[3] A STUDY OF THE ELECTROCHEMICAL OXIDATION OF NAVELBINE [J].

BRETT, AMO ;

GRAZINA, MMM ;

MACEDO, TRA ;

OLIVEIRA, C ;

RAIMUNDO, D .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1993, 11 (03) :203-206

[4] A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry [J].

Damena, Carola W. N. ;

Rosing, Hilde ;

Tibben, Matthijs M. ;

van Maanen, Maria J. ;

Lagas, Jurjen S. ;

Schinkel, Alfred H. ;

Schellens, Jan H. M. ;

Beijnena, Jos H. .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2008, 868 (1-2) :102-109

[5] DETERMINATION OF VINORELBINE (NAVELBINE) IN TUMOR-CELLS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

DEBAL, V ;

MORJANI, H ;

MILLOT, JM ;

ANGIBOUST, JF ;

GOURDIER, B ;

MANFAIT, M .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1992, 581 (01) :93-99

[6] Simultaneous determination of two active ingredients in Flos daturae by capillary electrophoresis with electrochemiluminescence detection [J].

Gao, Y ;

Tian, YL ;

Wang, EK .

ANALYTICA CHIMICA ACTA, 2005, 545 (02) :137-141

[7] High-performance liquid chromatographic determination of vinorelbine in human plasma and blood: application to a pharmacokinetic study [J].

Gauvin, AL ;

Pinguet, F ;

Poujol, S ;

Astre, C ;

Bressolle, F .

JOURNAL OF CHROMATOGRAPHY B, 2000, 748 (02) :389-399

[8] CHEMILUMINESCENCE DETECTION OF AMINO-ACIDS, PEPTIDES, AND PROTEINS USING TRIS-2,2'-BIPYRIDINE RUTHENIUM(III) [J].

HE, L ;

COX, KA ;

DANIELSON, ND .

ANALYTICAL LETTERS, 1990, 23 (02) :195-210

[9] Applications and trends in electrochemiluminescence [J].

Hu, Lianzhe ;

Xu, Guobao .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (08) :3275-3304

[10] Relationship between structural attributes and observed electrogenerated chemiluminescence (ECL) activity of tertiary amines as potential analytes for the tris(2,2-bipyridine)ruthenium(II) ECL reaction - A review [J].

Knight, AW ;

Greenway, GM .

ANALYST, 1996, 121 (11) :R101-R106

← 1 2 3 →