Ultrasound-Assisted Anti-Solvent Crystallization of Telmisartan Using Dimethyl Sulfoxide as Organic Solvent

被引：22

作者：

Sharma, Chetan ^{[1
]}

Desai, Meghal A. ^{[1
]}

Patel, Sanjaykumar R. ^{[1
]}

机构：

[1] Sardar Vallabhbhai Natl Inst Technol, Dept Chem Engn, Surat 395007, Gujarat, India

来源：

CRYSTAL RESEARCH AND TECHNOLOGY | 2018年 / 53卷 / 03期

关键词：

anti-solvent; dimethyl sulfoxide; particle size; telmisartan; ultrasound;

D O I：

10.1002/crat.201800001

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In recent years, ultrasound assisted anti-solvent crystallization has emerged as an excellent approach to reduce the particle size of poorly water-soluble drugs, thereby achieving improvement in the solubility and bioavailability. In the present study, this concept is employed for telmisartan by studying various critical parameters like the effect of sonication time, sonication amplitude, drug solution concentration, solvent to anti-solvent ratio, injection rate and crystallization temperature. The particle size of the commercial telmisartan is reduced from 10 mu m to 200 nm by anti-solvent crystallization method by applying 60% ultrasound amplitude for 15 min with 10mgmL(-1) drug concentration, 1:3 of solvent to anti-solvent ratio, and 10mL min(-1) of injection rate at 30 degrees C. Physicochemical characteristics; morphology, crystalline structure, the presence of other chemical compounds, enthalpy change, and the melting point of a recovered drug are analyzed using various analytical tools. It is possible to achieve nanoparticles of telmisartan by symbiotic effect of sonication with anti-solvent crystallization.

引用

页数：9

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