Polyunsaturated fatty acids and inflammation

被引：151

作者：

Marion-Letellier, Rachel ^{[1
,2
]}

Savoye, Guillaume ^{[1
,2
,3
]}

Ghosh, Subrata ^{[4
]}

机构：

[1] Univ Rouen, INSERM Unit UMR1073, F-76183 Rouen, France

[2] Rouen Univ Hosp, F-76183 Rouen, France

[3] Rouen Univ Hosp, Dept Gastroenterol, F-76031 Rouen, France

[4] Univ Calgary, Div Gastroenterol, Calgary, AB T2N 1N4, Canada

来源：

IUBMB LIFE | 2015年 / 67卷 / 09期

关键词：

Colitis; Crohn's disease; fatty acids; G-protein-mediated signaling; genetic models; NF-kB vertical bar AP-1; ACTIVATED-RECEPTOR-GAMMA; TNBS-INDUCED COLITIS; NF-KAPPA-B; RESOLVIN E1; N-3; PUFA; PROSTAGLANDIN D-2; GENE-EXPRESSION; TRANSGENIC MICE; CROHN-DISEASE; BOWEL-DISEASE;

D O I：

10.1002/iub.1428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammation is a protective process for life that aims to restore body homeostasis by targeting the injury and by inducing repair mechanisms. This process can also become excessive and lead to chronic inflammation and organ fibrosis. Polyunsaturated fatty acids play a key role in inflammatory processes and their resolution. Indeed, numerous lipid mediators derived from n-3 or n-6 PUFA such as eicosanoids, endocannabinoids, or proresolving lipids are able to target transcription factors to modulate gene expression. One other important action mechanism is by modification of cell membrane composition. The purpose of the present review is to describe the potential mechanisms by which PUFA influence inflammatory processes. To illustrate this purpose, we focused on the interactions between PUFA and intestinal inflammation as an integrative example. (c) 2015 IUBMB Life, 67(9):659-667, 2015

引用

页码：659 / 667

页数：9

共 68 条

[21] Transgenic Increase in N-3/N-6 Fatty Acid Ratio Reduces Maternal Obesity-Associated Inflammation and Limits Adverse Developmental Programming in Mice [J].

Heerwagen, Margaret J. R. ;

Stewart, Michael S. ;

de la Houssaye, Becky A. ;

Janssen, Rachel C. ;

Friedman, Jacob E. .

PLOS ONE, 2013, 8 (06)

[22] ChemR23, the Receptor for Chemerin and Resolvin E1, Is Expressed and Functional on M1 but Not on M2 Macrophages [J].

Herova, Magdalena ;

Schmid, Mattia ;

Gemperle, Claudio ;

Hersberger, Martin .

JOURNAL OF IMMUNOLOGY, 2015, 194 (05) :2330-2337

[23] Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes [J].

Hong, Song ;

Tian, Haibin ;

Lu, Yan ;

Laborde, James Monroe ;

Muhale, Filipe A. ;

Wang, Quansheng ;

Alapure, Bhagwat V. ;

Serhan, Charles N. ;

Bazan, Nicolas G. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2014, 307 (11) :C1058-C1067

[24] Diet and Inflammatory Bowel Disease: Review of Patient-Targeted Recommendations [J].

Hou, Jason K. ;

Lee, Dale ;

Lewisk, James .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2014, 12 (10) :1592-1600

[25] PPARγ is an E3 ligase that induces the degradation of NFκB/p65 [J].

Hou, Yongzhong ;

Moreau, France ;

Chadee, Kris .

NATURE COMMUNICATIONS, 2012, 3

[26] Stearidonic and Eicosapentaenoic Acids Inhibit Interleukin-6 Expression in ob/ob Mouse Adipose Stem Cells via Toll-Like Receptor-2-Mediated Pathways [J].

Hsueh, Hui Wen ;

Zhou, Zhou ;

Whelan, Jay ;

Allen, Kenneth G. D. ;

Moustaid-Moussa, Naima ;

Kim, Hyojung ;

Claycombe, Kate J. .

JOURNAL OF NUTRITION, 2011, 141 (07) :1260-1266

[27] A soybean and fish oil mixture with different n-6/n-3 PUFA ratios modulates the inflammatory reaction in mice with dextran sulfate sodium-induced acute colitis [J].

Huang, Cyoung-Huei ;

Hou, Yu-Chen ;

Yeh, Chiu-Li ;

Yeh, Sung-Ling .

CLINICAL NUTRITION, 2015, 34 (05) :1018-1024

[28] Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis [J].

Hudert, Christian A. ;

Weylandt, Karsten H. ;

Lu, Yan ;

Wang, Jingdong ;

Hong, Song ;

Dignass, Axel ;

Serhan, Charles N. ;

Kang, Jing X. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (30) :11276-11281

[29] Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells [J].

Hutchins, Heather L. ;

Li, Yong ;

Hannon, Kevin ;

Watkins, Bruce A. .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2011, 22 (02) :195-200

[30] Dietary α-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis [J].

Ibrahim, Ayman ;

Aziz, Moutaz ;

Hassan, Aktham ;

Mbodji, Khaly ;

Collasse, Elodie ;

Coeffier, Moise ;

Bounoure, Frederic ;

Savoye, Guillaume ;

Dechelotte, Pierre ;

Marion-Letellier, Rachel .

NUTRITION, 2012, 28 (7-8) :799-802

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