Polyunsaturated fatty acids and inflammation

被引：151

作者：

Marion-Letellier, Rachel ^{[1
,2
]}

Savoye, Guillaume ^{[1
,2
,3
]}

Ghosh, Subrata ^{[4
]}

机构：

[1] Univ Rouen, INSERM Unit UMR1073, F-76183 Rouen, France

[2] Rouen Univ Hosp, F-76183 Rouen, France

[3] Rouen Univ Hosp, Dept Gastroenterol, F-76031 Rouen, France

[4] Univ Calgary, Div Gastroenterol, Calgary, AB T2N 1N4, Canada

来源：

IUBMB LIFE | 2015年 / 67卷 / 09期

关键词：

Colitis; Crohn's disease; fatty acids; G-protein-mediated signaling; genetic models; NF-kB vertical bar AP-1; ACTIVATED-RECEPTOR-GAMMA; TNBS-INDUCED COLITIS; NF-KAPPA-B; RESOLVIN E1; N-3; PUFA; PROSTAGLANDIN D-2; GENE-EXPRESSION; TRANSGENIC MICE; CROHN-DISEASE; BOWEL-DISEASE;

D O I：

10.1002/iub.1428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammation is a protective process for life that aims to restore body homeostasis by targeting the injury and by inducing repair mechanisms. This process can also become excessive and lead to chronic inflammation and organ fibrosis. Polyunsaturated fatty acids play a key role in inflammatory processes and their resolution. Indeed, numerous lipid mediators derived from n-3 or n-6 PUFA such as eicosanoids, endocannabinoids, or proresolving lipids are able to target transcription factors to modulate gene expression. One other important action mechanism is by modification of cell membrane composition. The purpose of the present review is to describe the potential mechanisms by which PUFA influence inflammatory processes. To illustrate this purpose, we focused on the interactions between PUFA and intestinal inflammation as an integrative example. (c) 2015 IUBMB Life, 67(9):659-667, 2015

引用

页码：659 / 667

页数：9

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