Asymmetric split-ring resonator-based biosensor for detection of label-free stress biomarkers

被引：52
作者：
Lee, Hee-Jo [1 ]
Lee, Jung-Hyun [1 ]
Choi, Suji [2 ]
Jang, Ik-Soon [3 ]
Choi, Jong-Soon [3 ]
Jung, Hyo-Il [1 ,2 ]
机构：
[1] Yonsei Univ, Sch Mech Engn, Seoul 120749, South Korea
[2] Yonsei Univ, Nanomed Natl Res Core Ctr, Seoul 120749, South Korea
[3] Korea Basic Sci Inst, Div Life Sci, Taejon 169148, South Korea
来源：
APPLIED PHYSICS LETTERS | 2013年 / 103卷 / 05期
基金：
新加坡国家研究基金会;
关键词：
SALIVARY CORTISOL; METAMATERIALS; NANOWIRE; SUBWAVELENGTH; SENSITIVITY; RESONANCES; AMYLASE; DESIGN;
D O I：
10.1063/1.4816440
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
In this paper, an asymmetric split-ring resonator, metamaterial element, is presented as a biosensing transducer for detection of highly sensitive and label-free stress biomarkers. In particular, the two biomarkers, cortisol and alpha-amylase, are used for evaluating the sensitivity of the proposed biosensor. In case of cortisol detection, the competitive reaction between cortisol-bovine serum albumin and free cortisol is employed, while alpha-amylase is directly detected by its antigen-antibody reaction. From the experimental results, we find that the limit of detection and sensitivity of the proposed sensing device are about 1 ng/ml and 1.155 MHz/ng ml(-1), respectively. (C) 2013 AIP Publishing LLC.
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页数：5
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