A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells

被引：17

作者：

Liu, Xiling ^{[2
]}

Gu, Fangyuan ^{[3
]}

Zhou, Xinyi ^{[2
]}

Zhou, Wei ^{[1
]}

Zhang, Shuping ^{[2
]}

Cui, Lei ^{[3
]}

Guo, Ting ^{[1
]}

机构：

[1] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China

[2] Univ Shanghai Sci & Technol, Coll Sci, Shanghai 200093, Peoples R China

[3] Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China

来源：

RSC ADVANCES | 2020年 / 10卷 / 63期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

CAENORHABDITIS-ELEGANS; NITRIC-OXIDE; HYPOCHLORITE; MODEL; ROS;

D O I：

10.1039/d0ra06564a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peroxynitrite (ONOO-) is a potent biological oxidant that plays a significant role in diverse physiological and pathological processes. A novel fluorescent probe HCA-OH was developed for specific and sensitive detection of peroxynitrite, and displayed a significant fluorescence turn-on signal. With low cytotoxicity and good photostability, the probe HCA-OH could be applied in imaging ONOO- distribution in HepG2 cells and live C. elegans in real time. Therefore, the probe can be a promising tool for imaging in vivo.

引用

页码：38281 / 38286

页数：6

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