NATURALLY ACQUIRED IgM ANTIBODY RESPONSE TO THE C-TERMINAL REGION OF THE MEROZOITE SURFACE PROTEIN 1 OF PLASMODIUM VIVAX IN KOREA: USE FOR SERODIAGNOSIS OF VIVAX MALARIA

被引：9

作者：

Yeom, Joon-Sup ^{[1
]}

Kim, Eu-Suk ^{[1
]}

Lim, Kook-Jin ^{[1
]}

Oh, Jae-Hoon ^{[1
]}

Sohn, Mi-Jin ^{[1
]}

Yoo, Seung-Bum ^{[1
]}

Kim, Eunkyung ^{[1
]}

Bae, Ineui ^{[1
]}

Jung, Yun-Jae ^{[1
]}

Park, Jae-Won ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Dept Internal Med, Kangbuk Samsung Hosp, Seoul 110746, South Korea

来源：

JOURNAL OF PARASITOLOGY | 2008年 / 94卷 / 06期

关键词：

D O I：

10.1645/GE-1484.1

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The antibody levels against the C-terminal region of the merozoite surface protein 1 of Plasmodium vivax (PvMSP1c) Were measured in 276 patients with P. vivax malaria (patient group), 320 malaria-naive healthy individuals (Control group 1). and 70 malaria-naive individuals with various disorders (control group 2) using the immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA) and the direct sandwich ELISA. TO evaluate the antibody response during relapse. 5 relapsed patients were tested using the IgM capture ELISA. The IgM antibodies were negative in 99.7% of control group 1 and in 100% of control group 2; they were positive in 90.6% of the patient group. The total antibody levels were positive in 88.4% of the patient group with the direct sandwich ELISA. The sera from the second malaria episode. i.e., relapsed patients, were 100% positive on the IgM capture ELISA. The results of this study suggest that the IgM capture ELISA may be a useful diagnostic method for P. vivax malaria for both primary infection and relapse.

引用

页码：1410 / 1414

页数：5

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