Host versus flu: antibodies win a round?

被引：3
作者：
Brooke, Christopher B. [1 ]
Yewdell, Jonathan W. [1 ]
机构：
[1] NIAID, Viral Dis Lab, Bethesda, MD 20892 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 03期
关键词：
MONOCLONAL-ANTIBODIES; INFLUENZA; HEMAGGLUTININ; SITES; HIV-1; H2N2;
D O I：
10.1038/nsmb.2524
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structural and functional analyses of three neutralizing antibodies against influenza virus H2 HA may explain why this HA subtype has disappeared from circulation in the human population and point to a potential new avenue for antiflu therapeutics.
引用
收藏
页码：245 / 246
页数：2
相关论文
共 16 条
[11]   Vaccinate for the next H2N2 pandemic now [J].
Nabel, Gary J. ;
Wei, Chih-Jen ;
Ledgerwood, Julie E. .
NATURE, 2011, 471 (7337) :157-158
[12]   A Novel Small Molecule Inhibitor of Influenza A Viruses that Targets Polymerase Function and Indirectly Induces Interferon [J].
Ortigoza, Mila Brum ;
Dibben, Oliver ;
Maamary, Jad ;
Martinez-Gil, Luis ;
Leyva-Grado, Victor H. ;
Abreu, Pablo, Jr. ;
Ayllon, Juan ;
Palese, Peter ;
Shaw, Megan L. .
PLOS PATHOGENS, 2012, 8 (04)
[13]   Influenza Virus Evolution, Host Adaptation, and Pandemic Formation [J].
Taubenberger, Jeffery K. ;
Kash, John C. .
CELL HOST & MICROBE, 2010, 7 (06) :440-451
[14]   STRUCTURAL IDENTIFICATION OF THE ANTIBODY-BINDING SITES OF HONG-KONG INFLUENZA HEMAGGLUTININ AND THEIR INVOLVEMENT IN ANTIGENIC VARIATION [J].
WILEY, DC ;
WILSON, IA ;
SKEHEL, JJ .
NATURE, 1981, 289 (5796) :373-378
[15]   A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin [J].
Xu, Rui ;
Krause, Jens C. ;
McBride, Ryan ;
Paulson, James C. ;
Crowe, James E., Jr. ;
Wilson, Ian A. .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2013, 20 (03) :363-370
[16]   CHARACTERIZATION OF H2-INFLUENZA VIRUS HEMAGGLUTININ WITH MONOCLONAL-ANTIBODIES - INFLUENCE OF RECEPTOR SPECIFICITY [J].
YAMADA, A ;
BROWN, LE ;
WEBSTER, RG .
VIROLOGY, 1984, 138 (02) :276-286
12