Preparation of pH-Sensitive Polymers/Layered Double Hydroxide Hybrid Beads for Controlled Release of Insulin

被引：20

作者：

Mahkam, Mehrdad ^{[1
]}

Davatgar, Mina ^{[1
]}

Rezvani, Zolfaghar ^{[1
]}

Nejati, Kamellia ^{[2
]}

机构：

[1] Azarbaijan Univ Tarbiat Moallem, Dept Chem, Tabriz, Iran

[2] Payam Noor Univ, Tabriz Ctr, Dept Chem, Tabriz, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2013年 / 62卷 / 02期

关键词：

Drug delivery; insulin release; nanocomposites; pH-sensitive polymer; ZnAl LDH; LAYERED DOUBLE HYDROXIDES; IN-VITRO RELEASE; COMPOSITE; NANOCOMPOSITES; ADSORPTION;

D O I：

10.1080/00914037.2011.617337

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The present work introduces new hybrid material based on the combination of layered double hydroxides (LDH) and a pH-sensitive polymer (PSP), alginate, a polysaccharide widely applied for encapsulating drugs to produce a LDHpolymer nanocomposite, able to act as an effective drug delivery system (DDS) in comparison to the ZnAl LDH or the polymer alone. Insulin has been chosen as a model drug, being loaded in a ZnAl LDH matrix. In vitro release profiles were established separately in both the presence and absence of glucose phosphate in pH 7. Drug release studies showed that the in the presence of glucose phosphate release rate increases.

引用

页码：57 / 60

页数：4

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