Microwave assisted synthesis of 1,5-disubstituted hydantoins and thiohydantoins in solvent-free conditions

被引：0
作者：
Paul, S [1 ]
Gupta, M
Gupta, R
Loupy, A
机构：
[1] Univ Jammu, Dept Chem, Jammu 180006, India
[2] Univ Paris 11, Lab React Select Supports, CNRS, UMR 8615, F-91405 Orsay, France
来源：
SYNTHESIS-STUTTGART | 2002年 / 01期
关键词：
arylglyoxals; solvent-free conditions; polyphosphoric ester (PPE); microwave activation; hydantoins;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,5-Disubstituted hydantoins/thiohydantoins 3a-p have been synthesized in 81-95% yield by a microwave-promoted solvent-free condensation of arylglyoxals 1 and phenylurea/thiourea 2 using PPE as a reaction mediator. This method can be extended towards the parallel synthesis of 3. The workup is simple and involves treatment with ice-cold water.
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页码：75 / 78
页数：4
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