Polarized sorting and trafficking in epithelial cells

被引：112

作者：

Cao, Xinwang ^{[1
,2
]}

Surma, Michal A. ^{[1
]}

Simons, Kai ^{[1
]}

机构：

[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

[2] Anhui Med Univ, Sch Life Sci, Hefei 230032, Anhui, Peoples R China

来源：

CELL RESEARCH | 2012年 / 22卷 / 05期

关键词：

epithelial polarity; lipid rafts; polarized sorting; INFLUENZA-VIRUS HEMAGGLUTININ; GPI-ANCHORED PROTEINS; TRANS-GOLGI NETWORK; PLASMA-MEMBRANE; APICAL TRANSPORT; LIPID RAFTS; N-GLYCANS; RECYCLING ENDOSOMES; SECRETORY VESICLES; TARGETING SIGNAL;

D O I：

10.1038/cr.2012.64

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the formation of an apical and a basolateral domain, which are separated by tight junctions. The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo molecules. This dynamic process involves the interaction of sorting signals with sorting machineries and the formation of transport carriers. Here we review the recent advances in the field of polarized sorting in epithelial cells. We especially highlight the role of lipid rafts in apical sorting.

引用

页码：793 / 805

页数：13

共 166 条

[1] Fission of a multiphase membrane tube [J].

Allain, JM ;

Storm, C ;

Roux, A ;

Amar, MB ;

Joanny, JF .

PHYSICAL REVIEW LETTERS, 2004, 93 (15) :158104-1

[2] The apical compartment: trafficking pathways, regulators and scaffolding proteins [J].

Altschuler, Y ;

Hodson, C ;

Milgram, SL .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (04) :423-429

[3] Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells [J].

Ang, AL ;

Taguchi, T ;

Francis, S ;

Fölsch, H ;

Murrells, LJ ;

Pypaert, M ;

Warren, G ;

Mellman, I .

JOURNAL OF CELL BIOLOGY, 2004, 167 (03) :531-543

[4] MUTATIONAL AND SECONDARY STRUCTURAL-ANALYSIS OF THE BASOLATERAL SORTING SIGNAL OF THE POLYMERIC IMMUNOGLOBULIN RECEPTOR [J].

AROETI, B ;

KOSEN, PA ;

KUNTZ, ID ;

COHEN, FE ;

MOSTOV, KE .

JOURNAL OF CELL BIOLOGY, 1993, 123 (05) :1149-1160

[5] Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cells [J].

Au, Josephine Sui-Yan ;

Puri, Claudia ;

Ihrke, Gudrun ;

Kendrick-Jones, John ;

Buss, Folma .

JOURNAL OF CELL BIOLOGY, 2007, 177 (01) :103-114

[6] Cystic kidney diseases and planar cell polarity signaling [J].

Bacallao, R. L. ;

McNeill, H. .

CLINICAL GENETICS, 2009, 75 (02) :107-117

[7] Signals for sorting of transmembrane proteins to endosomes and lysosomes [J].

Bonifacino, JS ;

Traub, LM .

ANNUAL REVIEW OF BIOCHEMISTRY, 2003, 72 :395-447

[8] Apical targeting and Golgi retention signals reside within a 9-amino acid sequence in the copper-ATPase, ATP7B [J].

Braiterman, Lelita ;

Nyasae, Lydia ;

Guo, Yan ;

Bustos, Rodrigo ;

Lutsenko, Svetlana ;

Hubbard, Ann .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2009, 296 (02) :G433-G444

[9] MECHANISM OF MEMBRANE ANCHORING AFFECTS POLARIZED EXPRESSION OF 2 PROTEINS IN MDCK CELLS [J].

BROWN, DA ;

CRISE, B ;

ROSE, JK .

SCIENCE, 1989, 245 (4925) :1499-1501

[10] SORTING OF GPI-ANCHORED PROTEINS TO GLYCOLIPID-ENRICHED MEMBRANE SUBDOMAINS DURING TRANSPORT TO THE APICAL CELL-SURFACE [J].

BROWN, DA ;

ROSE, JK .

CELL, 1992, 68 (03) :533-544

← 1 2 3 4 5 6 7 8 9 10 →