Polarized sorting and trafficking in epithelial cells

被引：109
作者：
Cao, Xinwang [1 ,2 ]
Surma, Michal A. [1 ]
Simons, Kai [1 ]
机构：
[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
[2] Anhui Med Univ, Sch Life Sci, Hefei 230032, Anhui, Peoples R China
来源：
CELL RESEARCH | 2012年 / 22卷 / 05期
关键词：
epithelial polarity; lipid rafts; polarized sorting; INFLUENZA-VIRUS HEMAGGLUTININ; GPI-ANCHORED PROTEINS; TRANS-GOLGI NETWORK; PLASMA-MEMBRANE; APICAL TRANSPORT; LIPID RAFTS; N-GLYCANS; RECYCLING ENDOSOMES; SECRETORY VESICLES; TARGETING SIGNAL;
D O I：
10.1038/cr.2012.64
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the formation of an apical and a basolateral domain, which are separated by tight junctions. The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo molecules. This dynamic process involves the interaction of sorting signals with sorting machineries and the formation of transport carriers. Here we review the recent advances in the field of polarized sorting in epithelial cells. We especially highlight the role of lipid rafts in apical sorting.
引用
收藏
页码：793 / 805
页数：13
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