Chemical speciation of nanoparticles surrounding metal-on-metal hips

被引:42
作者
Goode, Angela E. [1 ]
Perkins, James M. [1 ]
Sandison, Ann [2 ]
Karunakaran, Chithra [3 ]
Cheng, Huikai
Wall, David
Skinner, John A. [4 ]
Hart, Alister J. [5 ]
Porter, Alexandra E. [1 ]
McComb, David W. [1 ,6 ]
Ryan, Mary P. [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London, England
[2] Royal Natl Orthopaed Hosp, Dept Orthopaed, London, England
[3] Canadian Light Source, Saskatoon, SK, Canada
[4] UCL, Ctr Clin Orthopaed, London, England
[5] Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp, London, England
[6] Ohio State Univ, Dept Mat Sci & Engn, Columbus, OH 43210 USA
基金
英国工程与自然科学研究理事会; 欧洲研究理事会;
关键词
CORROSION PRODUCTS; WEAR PARTICLES; HYPERSENSITIVITY; ARTHROPLASTY; PROSTHESES; TISSUE;
D O I
10.1039/c2cc33016d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Spectromicroscopy of tissue surrounding failed CoCr metal-on-metal hip replacements detected corroded nanoscale debris in periprosthetic tissue in two chemical states, with concomitant mitochondrial damage. The majority of debris contained Cr3+, with trace amounts of oxidised cobalt. A minority phase containing a core of metallic chromium and cobalt was also observed.
引用
收藏
页码:8335 / 8337
页数:3
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