Topography of age-related changes in sleep spindles

被引：179
作者：
Martin, Nicolas [1 ,2 ,3 ]
Lafortune, Marjolaine [1 ,2 ,3 ]
Godbout, Jonathan [4 ]
Barakat, Marc [1 ,2 ,3 ]
Robillard, Rebecca [1 ,2 ]
Poirier, Gaetan [2 ]
Bastien, Celyne [5 ,6 ]
Carrier, Julie [1 ,2 ,3 ]
机构：
[1] Hop Sacre Coeur Montreal, Ctr Adv Res Sleep Med, Montreal, PQ H4J 1C5, Canada
[2] Univ Montreal, Dept Psychol, Montreal, PQ H3C 3J7, Canada
[3] Geriatr Inst Montreal, Res Ctr, Montreal, PQ, Canada
[4] Ecole Technol Super, Montreal, PQ, Canada
[5] Univ Laval, Sch Psychol, Quebec City, PQ, Canada
[6] Robert Giffard Res Ctr, Lab Neurosci Comportementales Humaines, Quebec City, PQ, Canada
来源：
NEUROBIOLOGY OF AGING | 2013年 / 34卷 / 02期
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词：
Sleep spindles; Aging; Topography; Eeg; FREQUENCY ACTIVITY; DEPENDENT CHANGES; CEREBRAL-CORTEX; YOUNG-ADULT; EEG; BRAIN; OSCILLATIONS; GENDER; POWER; INCREASES;
D O I：
10.1016/j.neurobiolaging.2012.05.020
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aging induces multiple changes to sleep spindles, which may hinder their alleged functional role in memory and sleep protection mechanisms. Brain aging in specific cortical regions could affect the neural networks underlying spindle generation, yet the topography of these age-related changes is currently unknown. In the present study, we analyzed spindle characteristics in 114 healthy volunteers aged between 20 and 73 years over 5 anteroposterior electroencephalography scalp derivations. Spindle density, amplitude, and duration were higher in young subjects than in middle-aged and elderly subjects in all derivations, but the topography of age effects differed drastically. Age-related decline in density and amplitude was more prominent in anterior derivations, whereas duration showed a posterior prominence. Age groups did not differ in all-night spindle frequency for any derivation. These results show that age-related changes in sleep spindles follow distinct topographical patterns that are specific to each spindle characteristic. This topographical specificity may provide a useful biomarker to localize age-sensitive changes in underlying neural systems during normal and pathological aging. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：468 / 476
页数：9
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